Recombinant Mouse Interleukin-5 protein (Il5) (Active)

1. binding of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HSP70-1 via the eNOS signaling pathway. PMID: 28317868
2. IL-33 acts directly on bone marrow ILC2s, making them an early source of IL-5 and part of a process that is central in IL-33-driven eosinophilia. PMID: 28921511
3. Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 and GM-CSF. PMID: 28737771
4. these studies establish a basal defect in eosinophilopoiesis in IL-33- and ST2-deficient mice and a mechanism whereby IL-33 supports eosinophils by driving both systemic IL-5 production and the expansion of IL-5Ralpha-expressing precursor cells PMID: 27683753
5. Increased production of IL-5 from Peyer's patch cells and the restored Th1-type immune response might cause the production of abnormal IgA and might induce the glomerular deposition of IgA in IGA nephropathy. PMID: 26719095
6. selective proliferation of IgM rheumatoid factor-secreting B-1a cells is induced by co-stimulation by the specific pathogen antigen and IL-5 in the development of MC in Capillaria hepatica-infected mice PMID: 25452118
7. IL5, a cytokine involved in allergic and infectious diseases, facilitates metastatic colonization through recruitment of sentinel eosinophils and regulation of other inflammatory/immune cells in the microenvironment of the distal lung. PMID: 25691457
8. Data (including data from knockout mice) suggest that up-regulation of IL5 production in lungs during influenza virus infection is due to infiltration of natural killer cells and alveolar macrophages into infected lung tissue. PMID: 24068930
9. A decrease in the levels of IL-5, IL-9, and IL-6R in the BALF. PMID: 24246030
10. eosinophils express CAR4 following IL-5 or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inflammation PMID: 24808371
11. Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression. PMID: 23855447
12. Together, these studies support the conclusion that surfactant protein D increases susceptibility to Cryptococcus neoformans infection by promoting Cryptococcus neoformans-driven pulmonary IL-5 and eosinophil infiltration. PMID: 24478083
13. IL5 induced eosinophils and cysteinyl leukotrienes are involved in the pathology of mite antigen-induced chronic asthma model. PMID: 23942524
14. Id3 is a key regulator of natural helper cell IL-5 production and B-1a B cell homeostasis. PMID: 24115031
15. Interleukin-5 plays a key role in mouse strain- dependent susceptibility to contact hypersensitivity through its effects on initiator B cells. PMID: 23711860
16. macrophage IL-5 is a target gene for LXR activation, and the induction of macrophage IL-5 expression can be related to LXR-inhibited atherosclerosis. PMID: 23150660
17. Ang II induces increased Th2 cytokines IL-5 and IL-10 early in the course of experimental abdominal aortic aneurysm formation, and inhibition of IL-5 prevents AAA formation suggesting an important role. PMID: 22459292
18. Sex difference in IL-5 production by splenocytes might be due, at least in part, to the sex difference in the sensitivity of CD4+ T cells to suppression by CD8+ T cells. PMID: 22627364
19. Invading tumor cells enhance and increase local IL-5 production from innate IL-5-producing non-T lymphoid cells residing in the intestine, peritoneal cavity and lungs of naive mice. PMID: 22174445
20. PARP-1 regulates Il-5 production through calpain degradation of STAT-6 in a murine asthma model. PMID: 21276008
21. IL-5 production by splenocytes triggered by TCR activation was higher in female mice than in male mice, and the difference might be attributable to sex differences in CD4+ and CD8+ T cell functions. PMID: 21646791
22. Transnasal administration of liposome- mediated IL12 could depress the expression of IL-5 in bone marrow, peripheral blood, and nasal mucosa in allergic rhinitis. PMID: 19954023
23. Exacerbation of oxazolone colitis by infection with the helminth Hymenolepis diminuta: involvement of IL-5 and eosinophils. PMID: 21037078
24. Greater antigen-induced Th2 IL-5 production by bronchial lymph node cells from female mice was associated with enhanced Th2 cell differentiation and increased expression of the Th2-specific transcription factor, GATA-3. PMID: 20337994
25. IL-5 production by bronchial epithelial cells can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways PMID: 20494340
26. IL-5 promotes eosinophil trafficking to the esophagus PMID: 11859139
27. IL-5 is required for the development of tissue and marrow eosinophilia, the formation of eosinophil/basophil colony-forming units, and the early development of symptoms in experimental allergic rhinitis. PMID: 11884474
28. Role of IL-5 during primary and secondary immune response to acetylcholine receptor. PMID: 11960640
29. mechanism of synergism between eotaxin and IL5, facilitating the selective recruitment of eosinophils into sites of allergic inflammation PMID: 12083417
30. A putative Bcl6-binding DNA sequence which acts as a silencer element has been identified in the 3' untranslated region of IL-5 cDNA. PMID: 12097386
31. IL-5 alone does not account for the complexities of bronchopulmonary hyperreactivity or of eosinophil tissue trapping PMID: 12231478
32. effects of constitutive interleukin-5 (IL-5) expression and overabundance of eosinophils on the development and function of the mammary gland, uterus, and ovary PMID: 12620930
33. IL-5 appears to be required for the accumulation of eosinophils and airway hyperresponsiveness in the inflammatory lung. PMID: 12660425
34. The ability of IL-13 to induce eosinophilic esophagitis was abolished in STAT6-deficient mice, nearly completely ablated in IL-5-deficient mice, and significantly diminished in eotaxin-1-deficient mice. PMID: 14598258
35. immune effector mechanisms in murine filarial infection are dependent on both IFN-gamma and IL-5, whose synergistic effects may be mediated, at least in part, by neutrophils for the control of adult worms. PMID: 14638787
36. These results suggest an important role for interleukin-5, eosinophils, alphaVbeta6 integrin, and TGF-beta in airway remodeling. PMID: 14966564
37. Pulmonary fibrosis lesions are abolished in sensitized and allergen-exposed IL-5 receptor-null mice, whereas they are markedly accentuated in IL-5 transgenic animals. PMID: 14975941
38. Marked impairment of the maintenance of mature B-1 lymphocyte survival and homeostatic proliferation is demonstrated by blocking IL-5 signals. The key question is to what extent IL-5 is involved in mature B-1 cell survival and homeostatic proliferation. PMID: 15128785
39. IL-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. PMID: 15162425
40. CD4(-)c-kit(-)CD3epsilon(-)IL-2Ralpha(+) Peyer's patch cells are capable of secreting a high level of IL-5 in response to IL-2 PMID: 15214040
41. IL-5 links adaptive and natural immunity for epitopes of oxidized LHDL and protects from arteriosclerosis. PMID: 15286809
42. Anti-IL-5 was able to reduce eosinophil numbers in all tissue compartments, as well as BrdU+ eosinophils and CD34+ progenitor cells, and in all instances to a greater extent than anti-IL-9. PMID: 15823208
43. the increase in airway eosinophilia seen with COX inhibition is dependent on IL-5, whereas the increase in airway hyperresponsiveness is not PMID: 16339565
44. IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice PMID: 16856933
45. It was found that MCA-induced tumor incidence and growth were significantly attenuated in IL-5 transgenic mice. PMID: 17371978
46. Il-5 level peaked at 7 dpi in bronchoalveolar lavage fluid. PMID: 17487773
47. IL-5 gene delivery suppresses sensitization to antigen (ovalbumin) by upregulating transforming growth factor beta 1-dependent signaling to CD4-expressing T cells, thus suppressing allergic airway inflammation. PMID: 17579048
48. cyclic AMP signals enhance histone H3 acetylation at the IL-5 promoter and the concerted binding of GATA-3 and NFATc to the promoter. PMID: 18772129
49. there is a reciprocal relationship between inducible nitric oxide synthase and poly(ADP-ribose) polymerase-1; expression of inducible nitric oxide synthase may be dispensable for eosinophilia after interleukin-5 production PMID: 18829681
50. Healing was significantly delayed in IL-5-overexpressing mice with wounds gaping wider and exhibiting impaired re-epithelialization PMID: 18839016

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KEGG: mmu:16191

STRING: 10090.ENSMUSP00000043369

UniGene: Mm.4461