IL5, or interleukin 5, is produced primarily by activated T cells, but also by certain human T-cell leukemia cell lines, EBV-transformed B cells, and eosinophils.The mechanism of action of IL5 involves binding to a specific cell-surface receptor, which consists of an IL-5Rα chain and a signaling subunit, βc, to form a high-affinity receptor.IL5 promotes differentiation and survival of eosinophils by low-affinity binding of IL-5Rα and then tightly binding to βc dimers. and binding to IL-5Rα, and then tightly binding to the βc dimer, IL5 activates downstream signaling pathways, such as the JAK/STAT pathway, and thus promotes eosinophil differentiation, maturation, activation, migration, and survival.
The biological significance of IL5 is mainly reflected in its role in the regulation of eosinophil-related biological processes. It plays a key role in the pathogenesis of parasitic infections and allergic diseases, especially in eosinophilia and certain allergic diseases, where IL5 levels are increased.IL5 enhances the ability of eosinophils to kill tumor cells and pathogens by promoting their proliferation and activation, as well as playing an important role in mucosal immunity. In addition, IL5 is involved in the regulation of B-cell differentiation and antibody production, and is particularly synergistic in IgA synthesis. Thus, IL5 is an important cytokine in the immune response and has a significant impact on the maintenance of immune homeostasis and defense mechanisms.
Recombinant Human Interleukin-5 (IL5) (CSB-MP011662HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of IL5 was greater than 95% as determined by SEC-HPLC
Validated Data
Western Blot analysis of HuvEc cells using IL-5 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using CSB-PA003033 at dilution of 1:100
Rat Interleukin 5,IL-5 ELISA KIT (CSB-E07435r)
Validated Data
Code: CSB-E07435r
Size: 96T,5×96T,10×96T
Sensitivity: 3.9 pg/mL
Detection Range: 15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following IL5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL5 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA003033 | IL5 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011662XA01HU | IL5 Antibody | Homo sapiens (Human) | ELISA, WB (ensure identification of antigen) |
IL5 Antibodies for Sus scrofa (Pig)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA863067ZA01PI | IL5 Antibody | Sus scrofa | ELISA, WB (ensure identification of antigen) |
IL5 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP011662MOW CSB-EP011662MOW CSB-BP011662MOW CSB-MP011662MOW CSB-EP011662MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP003091MOW | Recombinant Rhesus Macaque Interleukin-5 protein (IL5) (Active) | E.Coli |
IL5 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP011662BO CSB-EP011662BO CSB-BP011662BO CSB-MP011662BO CSB-EP011662BO-B |
Recombinant Bovine Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP011662HU CSB-BP011662HU CSB-EP011662HU-B |
Recombinant Human Interleukin-5 (IL5) | E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-AP001721HU | Recombinant Human Interleukin-5 protein (IL5) (Active) | E.Coli |
CSB-YP011662HU | Recombinant Human Interleukin-5 (IL5) | Yeast |
CSB-AP004291HU | Recombinant Human Interleukin-5 (IL5) (Active) | Mammalian cell |
CSB-MP011662HU | Recombinant Human Interleukin-5 (IL5) | Mammalian cell |
CSB-MP011662HUa0 | Recombinant Human Interleukin-5 (IL5) | Mammalian cell |
CSB-YP011662HUa0 | Recombinant Human Interleukin-5 (IL5) | Yeast |
IL5 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP011662MO CSB-EP011662MO CSB-BP011662MO CSB-MP011662MO CSB-EP011662MO-B |
Recombinant Mouse Interleukin-5 (Il5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP003311MO | Recombinant Mouse Interleukin-5 protein (Il5) (Active) | E.Coli |
IL5 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP011662HO CSB-EP011662HO CSB-BP011662HO CSB-MP011662HO CSB-EP011662HO-B |
Recombinant Horse Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP011662GU CSB-EP011662GU CSB-BP011662GU CSB-MP011662GU CSB-EP011662GU-B |
Recombinant Guinea pig Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP011662CA CSB-EP011662CA CSB-BP011662CA CSB-MP011662CA CSB-EP011662CA-B |
Recombinant Cat Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Code | Product Name | Source |
---|---|---|
CSB-YP011662DRI CSB-EP011662DRI CSB-BP011662DRI CSB-MP011662DRI CSB-EP011662DRI-B |
Recombinant Cercocebus atys Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP637909SH CSB-EP637909SH CSB-BP637909SH CSB-MP637909SH CSB-EP637909SH-B |
Recombinant Sheep Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
Code | Product Name | Source |
---|---|---|
CSB-YP733829MRA CSB-EP733829MRA CSB-BP733829MRA CSB-MP733829MRA CSB-EP733829MRA-B |
Recombinant Meriones unguiculatus Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP842539DO CSB-EP842539DO CSB-BP842539DO CSB-MP842539DO CSB-EP842539DO-B |
Recombinant Dog Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Sigmodon hispidus (Hispid cotton rat)
Code | Product Name | Source |
---|---|---|
CSB-YP861706SZK CSB-EP861706SZK CSB-BP861706SZK CSB-MP861706SZK CSB-EP861706SZK-B |
Recombinant Sigmodon hispidus Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP863067PI | Recombinant Pig Interleukin-5 (IL5) | Yeast |
CSB-EP863067PI | Recombinant Pig Interleukin-5 (IL5) | E.coli |
CSB-BP863067PI CSB-MP863067PI CSB-EP863067PI-B |
Recombinant Pig Interleukin-5 (IL5) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 Proteins for Macropus eugenii (Tammar wallaby) (Notamacropus eugenii)
Code | Product Name | Source |
---|---|---|
CSB-YP895944MPE CSB-EP895944MPE CSB-BP895944MPE CSB-MP895944MPE CSB-EP895944MPE-B |
Recombinant Macropus eugenii Interleukin-5 (IL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL5 ELISA Kit for Cavia porcellus (Guinea pig)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12064Gp | Guinea pig interleukin 5,IL-5 ELISA Kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL5 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04636h | Human Interleukin 5,IL-5 ELISA KIT | serum, plasma, tissue homogenates | 0.97 pg/ml |
IL5 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04637m | Mouse Interleukin 5,IL-5 ELISA KIT | serum, plasma, tissue homogenates | 3.9 pg/ml |
IL5 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07435r | Rat Interleukin 5,IL-5 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |