IL5

IL5, or interleukin 5, is produced primarily by activated T cells, but also by certain human T-cell leukemia cell lines, EBV-transformed B cells, and eosinophils.The mechanism of action of IL5 involves binding to a specific cell-surface receptor, which consists of an IL-5Rα chain and a signaling subunit, βc, to form a high-affinity receptor.IL5 promotes differentiation and survival of eosinophils by low-affinity binding of IL-5Rα and then tightly binding to βc dimers. and binding to IL-5Rα, and then tightly binding to the βc dimer, IL5 activates downstream signaling pathways, such as the JAK/STAT pathway, and thus promotes eosinophil differentiation, maturation, activation, migration, and survival.

The biological significance of IL5 is mainly reflected in its role in the regulation of eosinophil-related biological processes. It plays a key role in the pathogenesis of parasitic infections and allergic diseases, especially in eosinophilia and certain allergic diseases, where IL5 levels are increased.IL5 enhances the ability of eosinophils to kill tumor cells and pathogens by promoting their proliferation and activation, as well as playing an important role in mucosal immunity. In addition, IL5 is involved in the regulation of B-cell differentiation and antibody production, and is particularly synergistic in IgA synthesis. Thus, IL5 is an important cytokine in the immune response and has a significant impact on the maintenance of immune homeostasis and defense mechanisms.