Mouse IgG Fc fragment

Citations (1)

Code	CSB-NP005801m
MSDS	MSDS Datasheet
Size	$376
	Order now
Image	Warning: preg_replace(): Unknown modifier 'a' in /www/wwwroot/cusabio.com/caches/caches_template/20141113/content/show_product_protein.php on line 156
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Citations
Customer Reviews and Q&A

Product Details

Purity

>95% (SDS-PAGE)

Activity

Not test

Research Area

Immunology

Alternative Names

Fragment crystallizable region

Source

Mouse serum IgG digested with papain

Target Protein Sequence

Full length protein

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

PBS, pH 7.4

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Datasheet & COA

Please contact us to get it.

Description

Mouse IgG Fc fragment is a native protein with full length. This protein is purified from mouse serum IgG digested with papain. Its purity was determined by SDS-PAGE and reached up to 95%. It is presented the mass molecule around 30 kDa visualized on the gel. It has been validated in ELISA, WB and SDS-PAGE applications.
The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors known as Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. The Fc regions of IgG bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type.

Citations

A versatile platform for the tumor-targeted delivery of immune checkpoint-blocking immunoglobin G Jie Fan,Journal of controlled release : official journal of the Controlled Release Society,2021

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

Submit a Review here

Applications : biolayer interferometry

Review: Binding of IgBD-tri to IgG and its (Fab)2 or Fc fragment was analyzed by biolayer interferometry. Biotin_x005f_x0002_labeled Z-IgBD-tri was immobilized on a streptavidin-coated probe, which was immersed into solutions containing different concentrations (25–250 nM) of IgG or its fragments to assess association.

By Anonymous

Read more reviews >>

■ Q&A

I am wondering if I can know the molecular weight and amino acid sequence of mouse IgG Fc fragment.

Thanks for your inquiry. According to the product name you provided, the product should be a native protein instead of peptide.
CSB-NP005801m Mouse IgG Fc
This is a native protein and its molecular weight is 30-32KDa. There is no amino acid sequence.

It is stated as native protein in the information sheet sorry I mixed peptide and protein. Do you mean you don't have the information on its amino acid sequence? If that's the case, do you have any suggestion on data bank that I can search since I am not a protein person?

Very nice to receive your quick response.
You could use imgt database to search the sequence of CSB-NP005801m.
We have tried to search the sequence of this protein in imgt database but haven't found. You could have a try.
We're not sure why you would like to know the sequence of this native protein, because almost no customer ask for this information.
Native protein is naturally extracted and the sequence will not change, and will not make any influence on experiment.

Hello, I would like to inquire about CSB-NP005801m and CSB-NP005201Rb. Are they all digested with papain? Do you have human IgG?

For CSB-NP005801m and CSB-NP005201Rb, these two natural proteins were catalyzed by papain.
Yes, we supply Human IgG Fc fragment . The product code is CSB-NP005401h.

I am looking into your mouse IgG Fc fragment (code # CSB-NP005801m). In the description, it talks about IgA, IgD, IgM and IgE as well. I just want to confirm that this product is only the Fc fragment from IgG. Also, is there any differentiation among the different IgG subtypes?

This protein is purified mouse serum from IgG and then performed enzymatic digestion to obtain FC fragment, which may contain some IgA, IgD, IgM, and IgE.

Promotions