ADCY7 Antibody

Code CSB-PA006812
Size US$167
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Product Details

Uniprot No. P51828
Target Names ADCY7
Alternative Names ADCY7 antibody; KIAA0037Adenylate cyclase type 7 antibody; EC 4.6.1.1 antibody; ATP pyrophosphate-lyase 7 antibody; Adenylate cyclase type VII antibody; Adenylyl cyclase 7 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the Internal region of Human A Cyclase VII.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Protocols Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Gene References into Functions
  1. We discovered a 0.6% frequency missense variant in ADCY7. PMID: 28067910
  2. The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9. PMID: 25959651
  3. The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients. PMID: 26220344
  4. evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression. PMID: 22264442
  5. we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels. PMID: 21481845
  6. construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase PMID: 11665607
  7. The first cytoplasmic domain (residues 506-584) of adenylyl cyclase (AC) type VII is an internal regulatory subunit, interacting with a cardinal activator of AC (Gs alpha) and with the conserved first catalytic domain of type VII AC. PMID: 15581358
  8. Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice. PMID: 17135423
  9. AC7 is a specific downstream effector of the G(12/13) pathway PMID: 18541530
  10. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion PMID: 19008230

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Database Links

HGNC: 238

OMIM: 600385

KEGG: hsa:113

STRING: 9606.ENSP00000254235

UniGene: Hs.513578

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