ANPEP Antibody

1. Crosslinking of CD13 by mAb C or E is required to inhibit adhesion, as monovalent Fab fragments are not sufficient. Thus, C and E antibodies recognize a distinct epitope on CD13, and binding to this epitope interferes with both CD13-mediated cell adhesion and enzymatic activity. PMID: 29789790
2. Data indicate the expression of aminopeptidase N (CD13) in small cell lung cancer (SCLC) tumor and suggest pre-therapeutic CD13 analysis for testing as investigational predictive biomarker for patient selection. PMID: 29110838
3. CD13 may be a marker for onychofibroblasts within nail matrix onychodermis PMID: 28708295
4. This is the first report presenting CD13 and FLI1 as important mediators of resistance to BRAF inhibition with potential as drug targets in BRAF inhibitors refractory melanoma. PMID: 29048432
5. CD13 enrichment was correlated with early recurrences, and poor prognosis in patients with hepatocellular carcinoma. PMID: 29145632
6. Patients with acute myeloid leukemia developing leukemia-specific acute hypoxic respiratory failure within 15 days had higher CD13 expression by leukemic cells. PMID: 28323433
7. Data suggest that CNGRC-GG-D(KLAKLAK)2 peptide actively participates in the downregulation of aminopeptidase N/CD13. PMID: 26655501
8. CGRP and IL-4 positively regulated APN/CD13 expression and activity in psoriatic fibroblasts. PMID: 28387421
9. this study shows that CD13 significantly contributes to tissue infiltration by monocytic myeloid-derived suppressor cells and monocytes, thereby contributing to the pathogenesis of hepatic inflammation PMID: 28739875
10. data reveal a novel role for CD13 in inducing homotypic aggregation in neutrophils, which results in a transmigration deficiency; this mechanism may be relevant to neutrophil micro-aggregation in vivo PMID: 27467268
11. CD13 expression is associated with hepatoblastoma invasiveness and could be a novel prognostic marker for hepatoblastoma. PMID: 25682862
12. Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N and to measure their activity in cell lysates. PMID: 26449746
13. Data show that CD13 anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart. PMID: 26771355
14. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. PMID: 26311161
15. 14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis. PMID: 26208633
16. Alanyl aminopeptidase expression is confined to mature zymogenic chief cells and its expression is lost en route to metaplasia. PMID: 26514774
17. Aminopeptidase N activity in tissue and plasma from colorectal cancer patients is an independent prognostic factor of 5-year survival. PMID: 25929234
18. Expression of APN/CD13 is a potential unfavorable factor to predict the efficacy and prognosis of post-operative chemotherapy in NSCLC patients, especially in lung adenocarcinoma patients. PMID: 25879366
19. We identified a unique HCC line, Li-7, which not only shows heterogeneity for a CD13(+) CSC hierarchy, but also undergoes a "population change" upon CSC differentiation PMID: 25885470
20. This study permitted the identification of the novel human LAP1C isoform and partially unraveled the molecular basis of LAP1 regulation. PMID: 25461922
21. Together these experiments reveal potential enzymatic and signalling roles for APN in osteosarcoma and establish a starting point for an in-depth analysis of the role of APN in regulating invasiveness. PMID: 25340499
22. Postulate that the interaction of ADAM17 with CD13 and its downregulation following CD13 engagement has important implications in acute myeloid leukemia cells. PMID: 25246708
23. CD13 could play an important role as a T cell chemoattractant, in a positive feedback loop that contributes to rheumatoid arthritis synovitis. PMID: 25219368
24. This study showed that CD13 and CD33 expression associated with poor prognosis in patients with MM implicating the need of analysis of these markers in MM diagnosis. PMID: 24991573
25. Aberrant expression of CD13 in >/= 5% of blasts of patients with SR-aALL is an adverse prognostic factor, delineating a subgroup of patients with SR-aALL that should be considered for more aggressive treatment. PMID: 24411984
26. Molecular mechanisms regulating CD13-mediated adhesion. PMID: 24627994
27. CD13 participates in phagocytic processes in dendritic cells and macrophages. PMID: 24063007
28. Antigen CD13, by influencing the adipogenic potential of human amniotic mesenchymal stem cells, could be an in utero risk factor for obesity. PMID: 23488598
29. NGR-LDP could bind to CD13-expressing HT-1080 cells. PMID: 23206754
30. results indicate that APN/CD13 could be an important diagnostic biomarker and therapeutic target for Malignant fibrous histiocytoma . PMID: 23677132
31. Activities of aminopeptidases N and B and insulin-regulated aminopeptidase could be useful non-invasive biomarkers of Alzheimer's disease from the earliest stages. PMID: 23500679
32. High CD13 expression is associated with Philadelphia chromosome negative B cell acute lymphoblastic leukemia. PMID: 23643324
33. results showed that ANPEP downregulation in prostate cancer (PC) was frequently associated with aberrant promoter hypermethylation, suggesting that epigenetic mechanisms are involved in silencing of ANPEP in PC cells PMID: 23322201
34. CD13 expression plays a role in supporting the survival of cancer stem cells and that there is an epithelial-mesenchymal transition-associated reduction in reactive oxygen species elevation. PMID: 21879266
35. The hAPN crystal structure provides the first example of a dimeric M1 family member and the observed structural features provide novel insights into the mechanism of peptide processing and signal transduction. PMID: 22932899
36. Inhibiting CD13 with bestatin may enhance the differentiation-inducing activity of all-trans-retinoic acid in NB4 cells. PMID: 22040956
37. Coexpression of APN/CD13 correlated significantly with tumor type and neoangiogenesis in breast cancer. PMID: 21611838
38. Myeloid cell surface peptidase CD13 is highly and specifically expressed on a subset of dendritic cells (DCs) responsible for cross-presentation: transgenic CD8+ murine splenic DCs. PMID: 22544935
39. The overall effects of APN on the expression of fibronectin, tenascin-C, and MMPs in fibroblasts propose an important role for APN in the regulation of keratinocyte-mediated ECM remodeling and fibroblast contractile activity. PMID: 22065384
40. Staining of tissue microarrays generated from a large series of melanoma samples and control tissues demonstrated a higher APN expression in primary melanoma lesions when compared with nevi and metastases PMID: 22307972
41. A peptide-targeted gene vector for highly efficient receptor-mediated intracellular delivery is used to target gene loaded poly(lactic acid)-poly(ethylene glycol) nanoparticles to vascular endothelial cells overexpressing CD13. PMID: 21376765
42. Murine gamma-herpesvirus-68 glycoprotein (gp)150-specific T-cell receptor epitope transgene activates antiviral CD4+ T cells that are maintained throughout long-term infection and even during quiescent latency. PMID: 22079983
43. We identified a variant in each of 3 genes (RFC1, SCN1A, ANPEP) potentially implicated in susceptibility to severe neurological complications in West Nile Virus disease. PMID: 21881118
44. APN expression and enzymatic function is reduced in aggressive meningiomas, and that alterations in the balance between APN and SPARC might favor meningioma invasion PMID: 19236378
45. analysis of the critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switching PMID: 20064928
46. Stromal aminopeptidase N expression correlates with angiogenesis in non-small-cell lung cancer. PMID: 19908113
47. data demonstrate that the glycosylation of aminopeptidase N at N291 blocks human coronavirus-229E infection PMID: 11774469
48. tested the hypothesis that CD13 influences proliferation of monocytoid cells by retarding the velocity of the cell cycle PMID: 11999577
49. CD13/APN is an important target of Ras signaling in angiogenesis and is a limiting factor in angiogenic progression. PMID: 12406907
50. inhibiting CD13/aminopeptidase N on the cell-surface of acute promyelocytic leukemia cells increases ATRA-induced differentiation PMID: 12443882
51. Binding of aminopeptidase N may trigger conformational changes in the coronavirus viral spike protein that facilitate virus entry. PMID: 12634402
52. DPPIV acts synergistically with this protein to regulate T cell function. PMID: 12675232
53. phosphorylation of Ets-2 by RAS/MAPK is a prerequisite for CD13/APN endothelial induction PMID: 14507917
54. CD13 has a characteristic canalicular distribution pattern and may have a role in cell polarization and bile compartmentalization in hepatocellular carcinomas PMID: 14767532
55. The activity of urinary alanine aminopeptidase as an index of alcohol-related kidney impairment is a valuable complement to the existing set of markers of chronic alcohol abuse. PMID: 15166647
56. HCoV-229E(human coronavirus) first binds to CD13 in the Triton X-100-resistant microdomain, then clusters CD13 by cross-linking, and thereby reaches the caveolar region before entering cells. PMID: 15280478
57. CD13 acts as a signal regulator of FcgammaR function. PMID: 15758076
58. TAL6 and CD13 can form a complex on lung cancer cells; these molecules can modulate cell migration and invasion, and the influence of CD13 on cell motility does not strictly depend on its aminopeptidase activity PMID: 15812828
59. Although hAPN-transgenic mice were resistant to HCoV-229E in vivo, primary embryonic cells and bone marrow dendritic cells were infected in vitro PMID: 15840518
60. results imply a novel functional role of CD13 and Fc gamma receptors as members of a multimeric receptor complex PMID: 15883031
61. Data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. PMID: 15916720
62. Aspirin may exert its anti-atherothrombotic effects in part via the inhibition of thrombin action by up-regulating APN/CD13 on endothelial cells. PMID: 16216591
63. Findings suggest that APN is a multifunctional protein with important roles in vascular endothelial morphogenesis during angiogenesis. PMID: 16466852
64. Mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum PMID: 16469741
65. APN/CD13 regulates TNFalpha-induced apoptosis via inhibition of TNFRI shedding PMID: 16533817
66. bFGF expression upregulates CD13 expression in human melanoma cells and results in enhanced invasive capacity and metastatic behaviour of human melanoma cells. PMID: 16685268
67. Our data provide first evidence for a functional role of DP IV and APN in the sebaceous gland apparatus and for their inhibitors, used alone or in combination, as completely new substances possibly affecting acne pathogenesis in a therapeutic manner. PMID: 16778789
68. The expression of APN/CD13 for patients with NSCLC to be associated with a poor prognosis and angiogenesis. This is the first study to show the relationship between the expression of APN/CD13 and the prognosis of patients with NSCLC. PMID: 16818694
69. RECK protein interacts with MT1-MMP and CD13/aminopeptidase N and modulates their endocytic pathways PMID: 17329256
70. CD13 rapidly processed CXCL11, but not CXCL8, to generate truncated CXCL11 forms that had reduced binding, signaling, and chemotactic properties for lymphocytes and CXCR3- or CXCR7-transfected cells. PMID: 17363734
71. CD13 functions as a novel modulator of signal transduction and cell motility via its influence on specific plasma membrane organization, thus regulating angiogenesis. PMID: 17363739
72. Overexpression of ANPEP is associated with Barrett's adenocarcinomas PMID: 17636545
73. There was a positive correlation between APN/CD13 expression and migratory potential in various ovarian carcinoma cell lines with accordingly enhanced secretion of endogenous MMP-2. PMID: 17655775
74. Expression is frequenty decreased in chronic myelogenous leukemia. PMID: 17662271
75. Finally, exogenous addition of galectin-3 into HUVECs induced angiogenesis in an APN-dependent manner. PMID: 17888402
76. CD13 transcription is regulated by MAF via an atypical response element. PMID: 17897790
77. Enkephalin-degrading enzymes are present in human semen and may be involved in the control of sperm motility, mainly by the regulation of endogenous opioid peptides. PMID: 17953966
78. Data show that aminopeptidase N (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. PMID: 17999179
79. Data support that APN plays important roles in the regulation of arterial blood pressure and the pathogenesis of hypertension. PMID: 18008160
80. CD13 was expressed in 73% of acute myeloid leukemia patients, CD15 was expressed in 43% of patients, CD33 was expressed in 64% of patients, and CD34 was expressed in 66% of patients. PMID: 18085638
81. APN/CD13 inhibition by Ubenimex enhances radiosensitivity; APN/CD13 plays an important role in tumor progression in several human malignancies PMID: 18366676
82. Data suggest that detection of CD2 or CD13 expression in chronic lymphocytic leukemia (CLL) suggests familial CLL, and that CD38 expression does not carry the negative prognosis observed in sporadic CLL. PMID: 18431797
83. New direction for CD13 biology, where cell surface molecules act as true molecular interfaces that induce and participate in critical inflammatory cell interactions. PMID: 18495788
84. Demonstrates expression of immune system in granulocytes after heart surgery. PMID: 18605079
85. Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression. PMID: 18677709
86. CD13 and/or CD33 are sensitive but not entirely specific markers of anaplastic lymphoma kinase anaplastic large cell lymphomas and should not be misinterpreted as indicating myeloid sarcoma. PMID: 18794057
87. this study suggests a potential role of APN/CD13 in the pathobiology of head and neck squamous cell carcinoma. PMID: 19373777
88. neoplastic transformation may be facilitated by CD13. CD13 may thus be an important target for novel molecular therapy of early stage acute B-cell leukemia. PMID: 19562339
89. The percentage of CD13+CD4+CD25hiTreg cells among the CD4+CD25hiTreg population increased significantly and correlated with pathological stage in NSCLC PMID: 19597336

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HGNC: 500

OMIM: 151530

KEGG: hsa:290

STRING: 9606.ENSP00000300060

UniGene: Hs.1239