AREG Antibody

Datasheet
Code CSB-PA694774
Size US$299
Uniprot No. P15514
Image
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HepG2 cells, Hela cells, 231 cells, Primary antibody: CSB-PA694774(AREG Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Fusion protein of Human AREG
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,WB;ELISA:1:2000-1:5000,WB:1:500-1:2000
Relevance The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias amphiregulin
Immunogen Species Homo sapiens (Human)
Target Names AREG
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Subcellular Location Membrane, Single-pass membrane protein
Protein Families Amphiregulin family
Database Links

HGNC: 651

OMIM: 104640

KEGG: hsa:374

STRING: 9606.ENSP00000370227

UniGene: Hs.270833

Pathway ErbB signaling pathway
Hippo signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway

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