CALML5 Antibody

Code CSB-PA030035
Size US$100
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Product Details

Uniprot No.
Target Names
CALML5
Alternative Names
CALL5_HUMAN antibody; CALML5 antibody; Calmodulin like 5 antibody; Calmodulin-like protein 5 antibody; Calmodulin-like skin protein antibody; CLSP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the C-terminal region of Human CALML5.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds calcium. May be involved in terminal differentiation of keratinocytes.
Gene References into Functions
  1. CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners. PMID: 26545810
  2. CLSP is increased in the upper epidermis in exacerbated atopic dermatitis as compared to non-exacerbated atopic dermatitis and normal skin, revealing a role in re-establishing the epidermal barrier PMID: 24279918
  3. Ubiquitination of CALML5 in the nucleus is involved in the carcinogenesis of breast cancer in premenopausal women. PMID: 24146193
  4. CLSP is a physiological heterotrimeric humanin receptor agonist. PMID: 23519124
  5. An investigation of the cation-binding properties of CLSP and the ensuing conformational changes finds that, with its high- and low-affinity Ca+2+-binding sites and a pronounced effect of Mg2+, CLSP is more similar to troponin C than to calmodulin. PMID: 11969404
  6. abnormal elevated levels of CLSP, characteristic of psoriatic epidermis, were probably not due to an overexpression of the protein, but most likely the result of its non-degradation PMID: 16689864
  7. The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy. PMID: 16765896

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Tissue Specificity
Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.
Database Links

HGNC: 18180

OMIM: 605183

KEGG: hsa:51806

STRING: 9606.ENSP00000369689

UniGene: Hs.180142

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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