CALML5 Antibody

Datasheet

Code	CSB-PA873713HA01HU
Size	US$166
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Image	Western blot All lanes: CALML5 antibody at 2μg/ml + A431 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 16 kDa Observed band size: 16 kDa Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA873713HA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CALML5 Polyclonal antibody

Uniprot No.

Q9NZT1

Target Names

CALML5

Alternative Names

CALL5_HUMAN antibody; CALML5 antibody; Calmodulin like 5 antibody; Calmodulin-like protein 5 antibody; Calmodulin-like skin protein antibody; CLSP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Calmodulin-like protein 5 protein (2-146AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CALML5 Antibody (Product code: CSB-PA873713HA01HU) is Non-conjugated. For CALML5 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA873713HB01HU	CALML5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873713HC01HU	CALML5 Antibody, FITC conjugated
Biotin	CSB-PA873713HD01HU	CALML5 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Binds calcium. May be involved in terminal differentiation of keratinocytes.

Gene References into Functions

CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners. PMID: 26545810
CLSP is increased in the upper epidermis in exacerbated atopic dermatitis as compared to non-exacerbated atopic dermatitis and normal skin, revealing a role in re-establishing the epidermal barrier PMID: 24279918
Ubiquitination of CALML5 in the nucleus is involved in the carcinogenesis of breast cancer in premenopausal women. PMID: 24146193
CLSP is a physiological heterotrimeric humanin receptor agonist. PMID: 23519124
An investigation of the cation-binding properties of CLSP and the ensuing conformational changes finds that, with its high- and low-affinity Ca+2+-binding sites and a pronounced effect of Mg2+, CLSP is more similar to troponin C than to calmodulin. PMID: 11969404
abnormal elevated levels of CLSP, characteristic of psoriatic epidermis, were probably not due to an overexpression of the protein, but most likely the result of its non-degradation PMID: 16689864
The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy. PMID: 16765896

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Tissue Specificity

Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Database Links

HGNC: 18180

OMIM: 605183

KEGG: hsa:51806

STRING: 9606.ENSP00000369689

UniGene: Hs.180142

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway cAMP signaling pathway Estrogen signaling pathway Melanogenesis Vascular smooth muscle contraction Cellular senescence Ras signaling pathway Apelin signaling pathway cGMP-PKG signaling pathway Glucagon signaling pathway Insulin signaling pathway Phosphatidylinositol signaling system Rap1 signaling pathway Neurotrophin signaling pathway

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