CCNB2 Antibody

1. Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1), cyclin B2 (CCNB2) and c-myc (c-MYC) genes by binding to the conserved binding sites on their promoters or enhancers. PMID: 27183908
2. Data show that the cyclin B2 was overexpressed in bladder cancer tissue. PMID: 26706119
3. overexpression of CCNB2 protein is associated with clinical progression and poor prognosis in non-small cell lung cancer PMID: 26349989
4. Cyclin B1 and cyclin B2 are interchangeable for ability to promote G2 and M transition in HeLa cells. PMID: 24324638
5. there was no significance in the 5-year overall survival rates among the patients with squamous cell carcinoma between expressing lower and higher level of cyclin B2 mRNA PMID: 24375198
6. Suggest that cytoplasmic CCNB2 may function as an oncogene and could serve as a potential biomarker of unfavorable prognosis over short-term follow-up in breast cancer. PMID: 23282137
7. The relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher than that in normal controls and benign diseases group. Circulating CCNB2 mRNA level significantly correlated with cancer stage and metastasis status. PMID: 21161946
8. Data suggest that cyclin A2 helps initiate mitosis, in part through its effects on cyclin B1, and that cyclins B1 and B2 are particularly critical for the maintenance of the mitotic state. PMID: 20660152
9. Overexpression of B-type cyclins alters chromosomal segregation PMID: 11960377
10. p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function PMID: 12482752
11. cyclin B2 expression in colorectal adenocarcinoma is dependent on NF-Y PMID: 17289878
12. severe reduction by separate RNA interference of either cyclin B1 or cyclin B2 protein levels results in little or no alteration of the cell cycle and, more specifically, of mitosis progression PMID: 17533373
13. This gene may be used as a very reliable biomarker of lung adenocarcinoma. PMID: 17549666

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HGNC: 1580

OMIM: 602755

KEGG: hsa:9133

STRING: 9606.ENSP00000288207

UniGene: Hs.194698