CD274 Antibody

Datasheet
Code CSB-PA004911GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q9NZQ7
Protocols Western Blotting(WB) Protocol
Immunoprecipitation (IP) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Flow Cytometry (FC) Protocol
ELISA Protocol
Immunogen Human CD274
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB, IP, IHC, IF, FC, ELISA
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias CD274 molecule;CD274;B7-H;B7H1;MGC142294;MGC142296;PD-L1;PDCD1L1;PDCD1LG1;PDL1 ;
Immunogen Species Homo sapiens (Human)
Target Names CD274
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Endomembrane system, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, BTN/MOG family
Tissue Specificity Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Database Links

HGNC: 17635

OMIM: 605402

KEGG: hsa:29126

STRING: 9606.ENSP00000370989

UniGene: Hs.521989

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