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| Code | CSB-PA001535 |
| Size | US$167 |
| Uniprot No. | P24941 |
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| Immunogen | Synthesized peptide derived from Human Cdk2/Cdc2 around the non-phosphorylation site of T160. |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000 |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Alias | CDK2; CDKN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol |
| Target Names | CDK2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Cajal body, Cytoplasm, Endosome |
| Protein Families | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily |
| Database Links |
HGNC: 1771 OMIM: 116953 KEGG: hsa:1017 STRING: 9606.ENSP00000266970 UniGene: Hs.19192 |
| Pathway |
p53 signaling pathway
PI3K-Akt signaling pathway Cell cycle Cellular senescence FoxO signaling pathway |
CDK2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005061GA01HU | CDK2 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA912055 | Phospho-CDK2 (Thr160) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA906045 | CDK2 (Ab-160) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA228346 | Phospho-CDK2 (Thr14) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000498 | Phospho-CDK2 (T160) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA000682 | Phospho-CDK2 (T160) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA001533 | CDK2 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA001534 | CDK2 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA267352 | CDK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA125315 | CDK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA005061LB01HU | CDK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005061LC01HU | CDK2 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA005061LD01HU | CDK2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA005061A15phHU | Phospho-CDK2 (Y15) Antibody | Human | ELISA, WB, IHC, IP |
CDK2 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005061LA01HU | CDK2 Antibody | Human | ELISA, WB, IHC, IF, IP |
CDK2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP005061HU CSB-BP005061HU CSB-MP005061HU |
Recombinant Human Cyclin-dependent kinase 2(CDK2) | Yeast Baculovirus Mammalian cell |
| CSB-EP005061HU | Recombinant Human Cyclin-dependent kinase 2(CDK2) | E.coli |
2-hydroxyisobutyryl-HIST1H2BC (K12) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
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