CDK2 Antibody

^Datasheet

Specification
Target

Code	CSB-PA001535
Size	US$167
Uniprot No.	P24941
Image	Western Blot analysis of A431 cells using Cdk2/Cdc2 Polyclonal Antibody
Immunogen	Synthesized peptide derived from Human Cdk2/Cdc2 around the non-phosphorylation site of T160.
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Tested Applications	WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000
Form	Liquid
Conjugate	Non-conjugated
Storage Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype	IgG
Alias	CDK2; CDKN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase
Immunogen Species	Homo sapiens (Human)
Protocols	Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol
Target Names	CDK2
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Cajal body, Cytoplasm, Endosome
Protein Families	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links	HGNC: 1771 OMIM: 116953 KEGG: hsa:1017 STRING: 9606.ENSP00000266970 UniGene: Hs.19192
Pathway	p53 signaling pathway PI3K-Akt signaling pathway Cell cycle Cellular senescence FoxO signaling pathway

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CSB-YP005061HU CSB-BP005061HU CSB-MP005061HU	Recombinant Human Cyclin-dependent kinase 2(CDK2)	Yeast Baculovirus Mammalian cell
CSB-EP005061HU	Recombinant Human Cyclin-dependent kinase 2(CDK2)	E.coli

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