Cxcl11 Antibody

Code CSB-PA09289A0Rb
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA09289A0Rb at dilution of 1:100
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Cxcl11 Polyclonal antibody
Uniprot No.
Target Names
Cxcl11
Alternative Names
Cxcl11 antibody; Scyb11C-X-C motif chemokine 11 antibody; Interferon-inducible T-cell alpha chemoattractant antibody; I-TAC antibody; Small-inducible cytokine B11 antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse C-X-C motif chemokine 11 protein (22-98AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Cxcl11 Antibody (Product code: CSB-PA09289A0Rb) is Non-conjugated. For Cxcl11 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA09289B0Rb Cxcl11 Antibody, HRP conjugated ELISA
FITC CSB-PA09289C0Rb Cxcl11 Antibody, FITC conjugated
Biotin CSB-PA09289D0Rb Cxcl11 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The rabbit IgG polyclonal antibody was raised against the recombinant C-X-C motif chemokine 11 protein (22-98aa) expressed in mouse. The rabbit anti-serum collected antibody was affinity purified using Protein G, resulting in a purity of over 95%.

This rabbit anti-mouse Cxcl11 polyclonal antibody is capable of recognizing the mouse Cxcl11 protein and has been validated for use in ELISA and IHC. It can be utilized to detect the presence, quantify the level, or visualize the distribution of Cxcl11 protein in experimental settings.

Customer Reviews and Q&A

 Customer Reviews
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Applications : Immunofluorescence(IF)

Sample type: Tissue

Review: Representative images of immunofluorescent staining show that the stimulated production of these two chemokines in the corneas and conjunctivas of DS + PBS mice was largely inhibited in DS + 2%Ectoine mice.

By Anonymous

Target Background

Function
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Gene References into Functions
  1. although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain. PMID: 29712506
  2. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
  3. very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11. PMID: 24713654
  4. Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process. PMID: 24398292
  5. Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11. PMID: 24566892
  6. Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development. PMID: 22277947
  7. the CXCL11-heparin interaction has two different affinities for glycosaminoglycans PMID: 20363748
  8. I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression. PMID: 15030574
  9. I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes. PMID: 15178708
  10. Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge. PMID: 17889309
  11. homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis PMID: 11500837

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Subcellular Location
Secreted.
Protein Families
Intercrine alpha (chemokine CxC) family
Database Links

KEGG: mmu:56066

UniGene: Mm.131723

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