E2F1 Antibody

Datasheet
Code CSB-PA278734
Size US$167
Uniprot No. Q01094
Image
  • Western Blot analysis of MOUSE-BRAIN cells using Antibody diluted at 500
Immunogen Synthetic peptide from AA range: 100-170
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,ELISA;WB:1:500-10000ELISA:1:10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alias E2F1 RBBP3
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Target Names E2F1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters
Subcellular Location Nucleus
Protein Families E2F/DP family
Database Links

HGNC: 3113

OMIM: 189971

KEGG: hsa:1869

STRING: 9606.ENSP00000345571

UniGene: Hs.654393

Pathway Cell cycle
Cellular senescence

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