EIF2AK4 Antibody

Datasheet
Code CSB-PA868396ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9P2K8
Image
  • Western blot
    All lanes: EIF2AK4 antibody at 2μg/ml + Mouse lung tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 187, 184, 70 kDa
    Observed band size: 187 kDa

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA868396ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA868396ESR2HU at dilution of 1:100

Immunogen Recombinant Human eIF-2-alpha kinase GCN2 protein (1-300AA)
Raised in Rabbit
Species Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200
Relevance Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein), EIF2AK4, GCN2 KIAA1338
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names EIF2AK4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability
Involvement in disease Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2)
Subcellular Location Cytoplasm
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Tissue Specificity Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).
Database Links

HGNC: 19687

OMIM: 234810

KEGG: hsa:440275

STRING: 9606.ENSP00000263791

UniGene: Hs.656673

Pathway Autophagy
Protein processing in endoplasmic reticulum

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