EIF2AK4 Antibody

Datasheet
Code CSB-PA868396ESR1HU
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Uniprot No. Q9P2K8
Image
  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA868396ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA868396ESR1HU at dilution of 1:100

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human eIF-2-alpha kinase GCN2 protein (1-300AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Relevance Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein), EIF2AK4, GCN2 KIAA1338
Immunogen Species Human
Research Area Epigenetics and Nuclear Signaling
Target Names EIF2AK4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability
Involvement in disease Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2)
Subcellular Location Cytoplasm
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Tissue Specificity Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).
Database Links

HGNC: 19687

OMIM: 234810

KEGG: hsa:440275

STRING: 9606.ENSP00000263791

UniGene: Hs.656673

Pathway Autophagy
Protein processing in endoplasmic reticulum

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