EIF2AK4

The EIF2AK4 gene encodes a protein known as eukaryotic translation initiation factor 2 alpha kinase 4, also referred to as GCN2. This kinase phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), regulating protein synthesis. It is a key player in cellular stress responses, particularly in the unfolded protein response and amino acid deprivation. EIF2AK4 is implicated in various diseases, including pulmonary veno-occlusive disease (PVOD) and cancer. Drug development targeting EIF2AK4 inhibitors is ongoing, with potential applications in oncology, neurodegenerative disorders, and metabolic conditions.
Recent research has highlighted the therapeutic potential of EIF2AK4 inhibitors, which modulate stress responses and may treat diseases involving dysfunctional stress responses. These inhibitors target the EIF2AK4 kinase, altering the cell's stress response and potentially reducing the survival advantage of cancer cells. Clinical trials are underway to assess their safety and efficacy in humans, offering hope for new treatments across various diseases.