EIF2AK4 Antibody

Datasheet
Code CSB-PA007513GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q9P2K8
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human EIF2AK4
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias eukaryotic translation initiation factor 2 alpha kinase 4;EIF2AK4;GCN2;KIAA1338 ;
Immunogen Species Homo sapiens (Human)
Target Names EIF2AK4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability
Involvement in disease Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2)
Subcellular Location Cytoplasm
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Tissue Specificity Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).
Database Links

HGNC: 19687

OMIM: 234810

KEGG: hsa:440275

STRING: 9606.ENSP00000263791

UniGene: Hs.656673

Pathway Autophagy
Protein processing in endoplasmic reticulum

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