GFRAL Antibody

Code CSB-PA751020LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in:Mouse Liver tissue lysate
    All lanes: GFRAL antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 45 kDa
    Observed band size: 55 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GFRAL Polyclonal antibody
Uniprot No.
Target Names
GFRAL
Alternative Names
bA360D14.1 antibody; C6orf144 antibody; GDNF family receptor alpha-like antibody; Gfral antibody; GFRAL_HUMAN antibody; GRAL antibody; IVFI9356 antibody; UNQ9356 antibody; UNQ9356/PRO34128 antibody
Raised in
Rabbit
Species Reactivity
Human,mouse
Immunogen
Recombinant Human GDNF family receptor alpha-like protein (19-351AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description
GFRAL polyclonal antibody CSB-PA751020LA01HU was produced in the rabbits immunized by using the Recombinant Human GDNF family receptor alpha-like protein (19-351AA). The target protein GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand (GDF15), GFRAL will interact with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
This Rabbit anti-Homo sapiens (Human) GFRAL Polyclonal antibody was tested in WB, IHC and ELISA applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the FLG proteins of human or mouse-origin and may be used to detect the endogenous levels of FLG protein.

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Target Background

Function
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Subcellular Location
Cell membrane; Single-pass membrane protein; Extracellular side.
Protein Families
GDNFR family
Tissue Specificity
Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level). Detected at low levels in testis and adipose tissue.
Database Links

HGNC: 32789

OMIM: 617837

KEGG: hsa:389400

STRING: 9606.ENSP00000343636

UniGene: Hs.526967

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