IL1RL2 Antibody, Biotin conjugated

Code CSB-PA888016LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) IL1RL2 Polyclonal antibody
Uniprot No. Q9HB29
Target Names IL1RL2
Alternative Names IL 1 receptor related protein 2 antibody; IL 1Rrp2 antibody; IL 36R antibody; IL-1Rrp2 antibody; IL-36 receptor antibody; IL1 receptor related protein 2 antibody; IL1R rp2 antibody; IL1R-rp2 antibody; Il1rl2 antibody; IL1RRP2 antibody; IL36R antibody; ILRL2_HUMAN antibody; Interleukin 1 receptor like 2 antibody; Interleukin 1 receptor related protein 2 antibody; Interleukin-1 receptor-like 2 antibody; Interleukin-1 receptor-related protein 2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Interleukin-1 receptor-like 2 protein (20-218AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Gene References into Functions
  1. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
  2. All human blood lymphocytes express IL-36R. PMID: 27269181
  3. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
  4. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
  5. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
  6. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
  7. IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
  8. Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
  9. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
  10. IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Interleukin-1 receptor family
Tissue Specificity Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Database Links

HGNC: 5999

OMIM: 604512

KEGG: hsa:8808

STRING: 9606.ENSP00000264257

UniGene: Hs.659863

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