Name: IL1RL2 Antibody, FITC conjugated
Brand: CUSABIO
SKU: CSB-PA888016LC01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) IL1RL2 Polyclonal antibody
Uniprot No.	Q9HB29
Target Names	IL1RL2
Alternative Names	IL 1 receptor related protein 2 antibody; IL 1Rrp2 antibody; IL 36R antibody; IL-1Rrp2 antibody; IL-36 receptor antibody; IL1 receptor related protein 2 antibody; IL1R rp2 antibody; IL1R-rp2 antibody; Il1rl2 antibody; IL1RRP2 antibody; IL36R antibody; ILRL2_HUMAN antibody; Interleukin 1 receptor like 2 antibody; Interleukin 1 receptor related protein 2 antibody; Interleukin-1 receptor-like 2 antibody; Interleukin-1 receptor-related protein 2 antibody
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human Interleukin-1 receptor-like 2 protein (20-218AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	FITC
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Tested Applications	ELISA
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function	Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Gene References into Functions	Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278 All human blood lymphocytes express IL-36R. PMID: 27269181 The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344 single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043 The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811 The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592 IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739 Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259 These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422 IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408 Show More Hide All
Subcellular Location	Membrane, Single-pass type I membrane protein
Protein Families	Interleukin-1 receptor family
Tissue Specificity	Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Database Links	HGNC: 5999 OMIM: 604512 KEGG: hsa:8808 STRING: 9606.ENSP00000264257 UniGene: Hs.659863

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Code	CSB-PA888016LC01HU
Size	US$299
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IL1RL2 Antibody, FITC conjugated

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Target Data

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