Recombinant Human Interleukin-1 receptor-like 2(IL1RL2),partial

Code	CSB-YP888016HU
Size	Pls inquire
Source	Yeast
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Code	CSB-EP888016HU
Size	Pls inquire
Source	E.coli
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Code	CSB-EP888016HU-B
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP888016HU
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP888016HU
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Target Data

Product Details

Purity	>85% (SDS-PAGE)
Target Names	IL1RL2
Uniprot No.	Q9HB29
Alternative Names	IL 1 receptor related protein 2; IL 1Rrp2; IL 36R; IL-1Rrp2; IL-36 receptor; IL1 receptor related protein 2; IL1R rp2; IL1R-rp2; Il1rl2; IL1RRP2; IL36R; ILRL2_HUMAN; Interleukin 1 receptor like 2; Interleukin 1 receptor related protein 2; Interleukin-1 receptor-like 2; Interleukin-1 receptor-related protein 2
Species	Homo sapiens (Human)
Protein Length	Partial
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form	Lyophilized powder
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet	Please contact us to get it.

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Target Data

Function	Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Gene References into Functions	Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278 All human blood lymphocytes express IL-36R. PMID: 27269181 The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344 single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043 The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811 The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592 IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739 Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259 These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422 IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408 Show More Hide All
Subcellular Location	Membrane, Single-pass type I membrane protein
Protein Families	Interleukin-1 receptor family
Tissue Specificity	Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Database Links	HGNC: 5999 OMIM: 604512 KEGG: hsa:8808 STRING: 9606.ENSP00000264257 UniGene: Hs.659863