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IL1RL2 Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA888016MA1HU
Size US$210
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  • The Binding Activity of Human IL1RL2 with Anti-IL1RL2 Recombinant Antibody

    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL1RL2 (CSB-MP888016HU) at 2 μg/mL can bind Anti-IL1RL2 recombinant antibody. The EC50 is 23.85-32.68 ng/mL.
  • The Binding Activity of Human IL1RL2 with Anti-IL1RL2 Recombinant Antibody

    Activity:IL1RL2 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human IL1RL2 (CSB-MP888016HU) protein with an affinity constant of 0.513 nM as detected by MetaSPR Assay (WeSPRTM 200).
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Product Details

Uniprot No.
Q9HB29
Target Names
IL1RL2
Alternative Names
Interleukin-1 receptor-like 2 (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2), IL1RL2, IL1RRP2
Species Reactivity
Human
Immunogen
Recombinant Human IL1RL2 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
hIgG1
Clone No.
17E9
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, SPR
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:10000
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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IL1RL2 Antibodies

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Target Background

Function
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Gene References into Functions
  1. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
  2. All human blood lymphocytes express IL-36R. PMID: 27269181
  3. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
  4. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
  5. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
  6. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
  7. IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
  8. Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
  9. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
  10. IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Interleukin-1 receptor family
Tissue Specificity
Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Database Links

HGNC: 5999

OMIM: 604512

KEGG: hsa:8808

STRING: 9606.ENSP00000264257

UniGene: Hs.659863

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