Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-AP004541HU |
| Size | US$2376 |
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| Purity | Greater than 95% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Activity | The ED50 as determined by its ability to bind Human IL-1F5 in functional ELISA is less than 50 ug/ml. |
| Target Names | IL1RL2 |
| Uniprot No. | Q9HB29 |
| Research Area | Immunology |
| Alternative Names | IL 1 receptor related protein 2; IL 1Rrp2; IL 36R; IL-1Rrp2; IL-36 receptor; IL1 receptor related protein 2; IL1R rp2; IL1R-rp2; Il1rl2; IL1RRP2; IL36R; ILRL2_HUMAN; Interleukin 1 receptor like 2; Interleukin 1 receptor related protein 2; Interleukin-1 receptor-like 2; Interleukin-1 receptor-related protein 2 |
| Species | Homo sapiens (Human) |
| Source | Mammalian cell |
| Expression Region | 20-337aa |
| Complete Sequence | DGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAY |
| Mol. Weight | 63.1 kDa |
| Protein Length | Partial |
| Tag Info |
C-terminal hFc-tagged |
| Form | Lyophilized powder |
| Buffer | Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4 |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
| Troubleshooting and FAQs |
Protein FAQs |
| Storage Condition | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Shelf Life | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Lead Time | Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Datasheet & COA | Please contact us to get it. |
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| Function |
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
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| Gene References into Functions |
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| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Protein Families | Interleukin-1 receptor family |
| Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level. |
| Database Links |
HGNC: 5999 OMIM: 604512 KEGG: hsa:8808 STRING: 9606.ENSP00000264257 UniGene: Hs.659863 |
