JAK2 Antibody

Datasheet
Code CSB-PA003078
Size US$167
Uniprot No. O60674
Image
  • Western Blot analysis of HT29 cells using JAK2 Polyclonal Antibody
  • Western Blot analysis of PC3 KB NIH-3T3 cells using JAK2 Polyclonal Antibody
Immunogen Synthesized peptide derived from Human JAK2 around the non-phosphorylation site of Y1007.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names JAK2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins
Involvement in disease Budd-Chiari syndrome (BDCHS); Polycythemia vera (PV); Thrombocythemia 3 (THCYT3); Myelofibrosis (MYELOF); Leukemia, acute myelogenous (AML)
Subcellular Location Endomembrane system, Peripheral membrane protein, Cytoplasm, Nucleus
Protein Families Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Tissue Specificity Ubiquitously expressed throughout most tissues.
Database Links

HGNC: 6192

OMIM: 147796

KEGG: hsa:3717

STRING: 9606.ENSP00000371067

UniGene: Hs.656213

Pathway Chemokine signaling pathway
Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Necroptosis
Signaling pathways regulating pluripotency of stem cells
Th1 and Th2 cell differentiation
Th17 cell differentiation
Adipocytokine signaling pathway
AGE-RAGE signaling pathway in diabetic complications

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