JAK2, or Janus kinase 2, is a non-receptor tyrosine protein kinase involved in hematopoiesis and immune system signaling. It associates with various cytokine receptors, activating the JAK-STAT signaling pathway when cytokines bind to their receptors. JAK2 is essential for red blood cell production and immune cell activation. Its abnormal activation is linked to hematological malignancies, especially myeloproliferative neoplasms (MPNs), with mutations like the V617F site in the pseudokinase region being significant. JAK2 is a key target for MPN treatment, with inhibiting the JAK2-STAT signaling pathway being a prominent research direction.
Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial (CSB-EP011931HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.
JAK2 Recombinant Monoclonal Antibody (CSB-RA267127A0HU)
Validated Data
Immunofluorescence staining of Hela Cells with CSB-RA267127A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
The following JAK2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
JAK2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011931LA01HU | JAK2 Antibody | Human | ELISA |
CSB-PA951532 | Phospho-JAK2 (Tyr1007) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA202109 | JAK2 (Ab-1007) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA264562 | JAK2 (Ab-570) Antibody | Human,Rat | ELISA,IHC |
CSB-PA173118 | Phospho-JAK2 (Tyr221) Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA227783 | Phospho-JAK2 (Tyr931) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA212456 | Phospho-JAK2 (Tyr570) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA281490 | JAK2 (Ab-570) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA000562 | Phospho-JAK2 (Y1007) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA003078 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA003079 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA011286 | Phospho-JAK2 (Y570) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011287 | Phospho-JAK2 (Y221) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011288 | Phospho-JAK2 (Y931) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011289 | Phospho-JAK2 (Y119) Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA011290 | JAK2 Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA011291 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA164401 | JAK2 Antibody | Human,Rat | ELISA,IHC |
CSB-PA435870 | JAK2 Antibody | Human,Rat | ELISA,IHC |
CSB-PA406975 | JAK2 Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-MA181103 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-MA780030 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA011931A100phHU | Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP |
CSB-RA267127A0HU | JAK2 Recombinant Monoclonal Antibody | Human | ELISA, IF |
JAK2 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP011931PI CSB-EP011931PI CSB-BP011931PI CSB-MP011931PI CSB-EP011931PI-B |
Recombinant Pig Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP011931HU CSB-BP011931HU CSB-MP011931HU CSB-EP011931HU-B |
Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011931HU | Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial | E.coli |
JAK2 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP716150PYX CSB-EP716150PYX CSB-BP716150PYX CSB-MP716150PYX CSB-EP716150PYX-B |
Recombinant Pongo abelii Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP717274RA CSB-EP717274RA CSB-BP717274RA CSB-MP717274RA CSB-EP717274RA-B |
Recombinant Rat Tyrosine-protein kinase JAK2 (Jak2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP726782MO CSB-EP726782MO CSB-BP726782MO CSB-MP726782MO CSB-EP726782MO-B |
Recombinant Mouse Tyrosine-protein kinase JAK2 (Jak2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP745061CH CSB-EP745061CH CSB-BP745061CH CSB-MP745061CH CSB-EP745061CH-B |
Recombinant Chicken Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |