Phospho-JAK2 (Tyr1007) Antibody

Code CSB-PA951532
Product Type Polyclonal Antibody
Former Code(s) CSB-PA011348
Size US$360
Uniprot No. O60674
  • Western blot analysis of extracts from HT29 cells untreated or treated with IL-4 using JAK2(Phospho-Tyr1007) Antibody.
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK2(Phospho-Tyr1007) Antibody(left) or the same antibody preincubated with blocking peptide(right).
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K) derived from Human JAK2.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of JAK2 only when phosphorylated at tyrosine 1007.
Tested Applications ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100
Relevance Plays a role in leptin signaling and control of body weight

James C, et al. (2005) Nature. 434(7037): 1144-1148.
Argetsinger LS, et al. (2004) Mol Cell Biol. 24(11): 4955-4967.
Ungureanu D, et al. (2002) Mol Cell Biol. 22(10): 3316-3326.
Xie S, et al. (2001) Oncogene. 20(43): 6188-6195.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Clonality Polyclonal
Alias JAK-2; JAK2; Janus kinase 2; kinase Jak2;
Immunogen Species Homo sapiens (Human)
Target Names JAK2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins
Involvement in disease Budd-Chiari syndrome (BDCHS); Polycythemia vera (PV); Thrombocythemia 3 (THCYT3); Myelofibrosis (MYELOF); Leukemia, acute myelogenous (AML)
Subcellular Location Endomembrane system, Peripheral membrane protein, Cytoplasm, Nucleus
Protein Families Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Tissue Specificity Ubiquitously expressed throughout most tissues.
Database Links

HGNC: 6192

OMIM: 147796

KEGG: hsa:3717

STRING: 9606.ENSP00000371067

UniGene: Hs.656213

Pathway Chemokine signaling pathway
Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Th1 and Th2 cell differentiation
Th17 cell differentiation
Adipocytokine signaling pathway
AGE-RAGE signaling pathway in diabetic complications

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