KLKB1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA012461LD01HU
Size US$299
Uniprot No. P03952
Protocols ELISA Protocol
Immunogen Recombinant Human Plasma kallikrein protein (503-612AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain], KLKB1, KLK3
Immunogen Species Homo sapiens (Human)
Research Area Cardiovascular
Target Names KLKB1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Involvement in disease Prekallikrein deficiency (PKK deficiency)
Subcellular Location Secreted
Protein Families Peptidase S1 family, Plasma kallikrein subfamily
Database Links

HGNC: 6371

OMIM: 229000

KEGG: hsa:3818

STRING: 9606.ENSP00000264690

UniGene: Hs.237642

Pathway Complement and coagulation cascades

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