LEFTY2 Antibody

Datasheet

Code	CSB-PA991744
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA991744(LEFTY2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA991744(LEFTY2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA991744(LEFTY2 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O00292

Target Names

LEFTY2

Alternative Names

EBAF antibody; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) antibody; Endometrial bleeding associated factor antibody; Endometrial bleeding-associated factor antibody; Left right determination factor 2 antibody; Left right determination factor A antibody; Left-right determination factor 2 antibody; Left-right determination factor A antibody; LEFTA antibody; LEFTY 2 antibody; LEFTY2 antibody; LEFTYA antibody; LFTY2 transforming growth factor; beta -4 antibody; LFTY2; mouse; homolog of antibody; LFTY2_HUMAN antibody; MGC46222 antibody; Protein lefty 2 antibody; Protein lefty A antibody; Protein lefty-2 antibody; Protein lefty-A antibody; Protein lefty2 antibody; PSEC0024 antibody; TGF beta 4 antibody; TGF-beta-4 antibody; TGFB4 antibody; Transforming growth factor beta 4 antibody; Transforming growth factor beta-4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Full length fusion protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Gene References into Functions

functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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Involvement in disease

Left-right axis malformations (LRAM)

Subcellular Location

Secreted.

Protein Families

TGF-beta family

Tissue Specificity

Mesenchymal cells of the endometrial stroma.

Database Links

HGNC: 3122

OMIM: 601877

KEGG: hsa:7044

STRING: 9606.ENSP00000355785

UniGene: Hs.520187

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Oct4 -- The Gatekeeper of Pluripotency of Embryonic Stem Cells Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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