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LEFTY2 Antibody

Datasheet
Code CSB-PA012858ESR2HU
Size US$166
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Image
  • Western Blotting(WB) - LEFTY2 Antibody

    Western blot
    All lanes: LEFTY2 antibody at 2μg/ml + A431 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 41, 38 kDa
    Observed band size: 41 kDa

  • Immunohistochemistry(IHC) 1- LEFTY2 Antibody

    Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA012858ESR2HU at dilution of 1: 100

  • Immunohistochemistry(IHC) 2- LEFTY2 Antibody

    Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA012858ESR2HU at dilution of 1: 100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LEFTY2 Polyclonal antibody
Uniprot No.
O00292
Target Names
LEFTY2
Alternative Names
EBAF antibody; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) antibody; Endometrial bleeding associated factor antibody; Endometrial bleeding-associated factor antibody; Left right determination factor 2 antibody; Left right determination factor A antibody; Left-right determination factor 2 antibody; Left-right determination factor A antibody; LEFTA antibody; LEFTY 2 antibody; LEFTY2 antibody; LEFTYA antibody; LFTY2 transforming growth factor; beta -4 antibody; LFTY2; mouse; homolog of antibody; LFTY2_HUMAN antibody; MGC46222 antibody; Protein lefty 2 antibody; Protein lefty A antibody; Protein lefty-2 antibody; Protein lefty-A antibody; Protein lefty2 antibody; PSEC0024 antibody; TGF beta 4 antibody; TGF-beta-4 antibody; TGFB4 antibody; Transforming growth factor beta 4 antibody; Transforming growth factor beta-4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Left-right determination factor 2 protein (57-366AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Gene References into Functions
  1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
  2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
  3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
  4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
  5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
  6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
  7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
  8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
  9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
  10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
  11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
  12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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Involvement in disease
Left-right axis malformations (LRAM)
Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Mesenchymal cells of the endometrial stroma.
Database Links

HGNC: 3122

OMIM: 601877

KEGG: hsa:7044

STRING: 9606.ENSP00000355785

UniGene: Hs.520187

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