LSS Antibody

Code CSB-PA013216GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
LSS antibody; OSCLanosterol synthase antibody; EC antibody; 2,3-epoxysqualene--lanosterol cyclase antibody; Oxidosqualene--lanosterol cyclase antibody; OSC antibody; hOSC antibody
Raised in
Species Reactivity
Human LSS
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Gene References into Functions
  1. LSS gene mutation is associated with Congenital cataract. PMID: 29016354
  2. Lanosterol synthase gene polymorphisms influence both the salt sensitivity of BP and changes in circulating EO in response to a low salt diet. PMID: 26667413
  3. There were no significant differences in OSC mRNA expression at various stages of breast cancer, or between tumor and normal mammary cells. PMID: 25051231
  4. oxidosqualene cyclase is active as a monomer PMID: 14766201
  5. two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors PMID: 15525992
  6. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. PMID: 19119143

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Involvement in disease
Cataract 44 (CTRCT44)
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein Families
Terpene cyclase/mutase family
Tissue Specificity
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
Database Links

HGNC: 6708

OMIM: 600909

KEGG: hsa:4047

STRING: 9606.ENSP00000348762

UniGene: Hs.596543

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