Ms4a1 Antibody

Datasheet

Code	CSB-PA015007LA01MO
Size	US$166
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Image	Western blot All lanes: Ms4a1 antibody at 4µg/ml Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: 293T whole cell lysate Lane 4: HL60 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 32 kDa Observed band size: 32 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Ms4a1 Polyclonal antibody

Uniprot No.

P19437

Target Names

Ms4a1

Alternative Names

Ms4a1 antibody; Cd20 antibody; Ly-44 antibody; Ms4a2 antibody; B-lymphocyte antigen CD20 antibody; B-cell differentiation antigen Ly-44 antibody; Lymphocyte antigen 44 antibody; Membrane-spanning 4-domains subfamily A member 1 antibody; CD antigen CD20 antibody

Raised in

Rabbit

Species Reactivity

Mouse, Human

Immunogen

Recombinant Mouse B-lymphocyte antigen CD20 protein (111-291AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

The Ms4a1 Antibody (Product code: CSB-PA015007LA01MO) is Non-conjugated. For Ms4a1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA015007LB01MO	Ms4a1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA015007LC01MO	Ms4a1 Antibody, FITC conjugated
Biotin	CSB-PA015007LD01MO	Ms4a1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

Gene References into Functions

Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment PMID: 28533311
Galectin-1 has a role in driving lymphoma CD20 immunotherapy resistance in a mouse model PMID: 26888257
Results indicate that an antigen-specific B cell response towards intracellular pathogens can be generated during anti-CD20 depletion therapy. PMID: 26261496
this study demonstrates a role for CD20 in B cell activation and T-dependent humoral immunity. PMID: 23966626
CD20 is required for store-operated calcium entry in C2C12 myoblasts. PMID: 22982241
immunization of mice with the CD20 extracellular domain-6 using Freund's or QS-21 adjuvants was shown to exert significant biological effects in vivo with the pronounced depletion of splenic B cells. PMID: 20189250
type I CD20 antibody cytotoxicity critically depends on Fc receptor ITAM signaling PMID: 20354182
CD20 deficiency in humans results in impaired T cell-independent antibody responses. PMID: 20038800
review of structure, function, tissue and cell distribution PMID: 12144126
Anti-CD20 antibodies rapidly depleted the vast majority of circulating and tissue B cells in an isotype-restricted manner dependent on effector cell Fc receptor expression. PMID: 15210744
expression in bacterial cells; isolation and biophysical and structural studies PMID: 16285718
In mice treated with anti-CD20 mAb, development of arthritis was significantly reduced in comparison to control mAb-treated mice PMID: 18354225
involvement of CD20 in calcium influx PMID: 18474602

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.

Protein Families

MS4A family

Database Links

KEGG: mmu:12482

STRING: 10090.ENSMUSP00000126422

UniGene: Mm.4046

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Related pathways

Hematopoietic cell lineage Cell markers Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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