NLRX1 Antibody

1. Data show that NLRX1 specifically interacts with FASTKD5 and colocalizes with mitochondrial RNA granules. Further results suggest an important role of NLRX1 in regulating the post-transcriptional processing of mitochondrial RNA, which may have an important implication in bioenergetic adaptation during metabolic stress, oncogenic transformation and innate immunity. PMID: 29932989
2. genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (TRAF6 = TNF receptor associated factor-6) PMID: 29046236
3. Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma. PMID: 27105514
4. NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3. NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. PMID: 28967880
5. downregulated in brain injury following aneurysm PMID: 28993512
6. The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission. PMID: 28459883
7. we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID: 26876213
8. findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis PMID: 27393910
9. NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review) PMID: 26763980
10. NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha induced cell death and metabolism. PMID: 25639646
11. These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID: 25938787
12. Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation. PMID: 24429360
13. NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID: 23321557
14. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
15. Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. PMID: 22718770
16. NLRX1 attenuated IFN-I production & promoted autophagy during viral infection cells. NLRX1 interacts with TUFM. PMID: 22749352
17. NLRX1 interacts directly with RNA and suggestts a role for NLRX1 in recognition of intracellular viral RNA in antiviral immunity. PMID: 22386589
18. the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID: 20959452
19. function of NOD-like receptors in the antiviral response [REVIEW] PMID: 18466630
20. identification of NLRX1 as a check against mitochondrial antiviral responses--an intersection of three ancient cellular processes: NLR signalling, intracellular virus detection and the use of mitochondria as a platform for anti-pathogen signalling PMID: 18200010
21. These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses. PMID: 18219313
22. sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity PMID: 18397740
23. NLRX1 has a functional leader sequence and fully translocates to the mitochondrial matrix. PMID: 19692591

Show More

Hide All

HGNC: 29890

OMIM: 611947

KEGG: hsa:79671

STRING: 9606.ENSP00000292199

UniGene: Hs.524082