NR3C1 (Ab-226) Antibody

Datasheet
Code CSB-PA589113
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P04150
Image
  • Immunohistochemical analysis of paraffin-embedded human brain tissue using GR (Ab-226) antibody.
  • Western blot analysis of extracts from Jurkat cells, treated with EGF (200ng/ml, 15mins), using GR (Ab-226) antibody.
  • Western blot analysis of extracts from JK cells (Lane 2) and K562 cells (Lane 3), using GR(Ab-226) antiobdy. The lane on the left is treated with synthesized peptide.
Immunogen Synthesized non-phosphopeptide derived from Human GR around the phosphorylation site of serine 226/234/246 (L-L-S-P-L).
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous levels of total GR protein.
Tested Applications ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
Relevance Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Kyung Jin Kwak, J. Exp. Bot., Nov 2005; 56: 3007 - 3016.
Maite de Llanos, Hum. Reprod., Jan 2005; 20: 216 - 220.
M. Lynch, Mol. Hum. Reprod., Jul 2005; 11: 507 - 512.
Valeriya P. Makarenkova, J. Immunol., Feb 2006; 176: 2085 - 2094.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias GCR; GRL; GRL1; NR3C1; glucocorticoid receptor
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names NR3C1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Receptor for glucocorticoids (GC)
Involvement in disease Glucocorticoid resistance, generalized (GCCR)
Subcellular Location Isoform Alpha: Cytoplasm, Nucleus, Mitochondrion, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Note=After ligand activation, translocates from the cytoplasm to the nucleus, SUBCELLULAR LOCATION: Isoform Beta: Nucleus, Cytoplasm, Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm, SUBCELLULAR LOCATION: Isoform Alpha-B: Nucleus, Cytoplasm
Protein Families Nuclear hormone receptor family, NR3 subfamily
Tissue Specificity Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node
Database Links

HGNC: 7978

OMIM: 138040

KEGG: hsa:2908

STRING: 9606.ENSP00000231509

UniGene: Hs.122926

Related Products

NR3C1 Antibodies

NR3C1 Antibodies for Homo sapiens (Human)

NR3C1 Antibodies for Human

NR3C1 Proteins

NR3C1 Proteins for Homo sapiens (Human)

NR3C1 ELISA Kit

NR3C1 ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.