Osm Antibody, FITC conjugated

Code CSB-PA723970LC01RA
Size US$299
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Osm Polyclonal antibody
Uniprot No. Q65Z15
Target Names Osm
Alternative Names Osm antibody; Oncostatin-M antibody; OSM antibody
Raised in Rabbit
Species Reactivity Rat
Immunogen Recombinant Rat Oncostatin-M protein (26-207AA)
Immunogen Species Rattus norvegicus (Rat)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Gene References into Functions
  1. OSM is a key mediator for inducing differentiation of OC15-5 cells into hepatocytes PMID: 15743783
  2. In the immortalized mouse and primary cultured proliferative rat hepatocytes, treatment with OSM markedly increased mRNA and protein of claudin-2 together with formation of developed networks of TJ strands. PMID: 17434483
  3. OSM may not only play a role in the regulation of Sertoli cell proliferation and the initiation of spermatogenesis but may also play a role in the regulation of Leydig cell progenitor formation. PMID: 17996055
  4. Results indicate that osteosarcoma cells stably producing OSM do not develop resistance to this cytokine and thus could be a valuable new tool to study the anti-cancer effect of OSM in vivo. PMID: 19168167
Subcellular Location Secreted.
Protein Families LIF/OSM family
Tissue Specificity Widely expressed. Expressed at higher levels in liver, skin and spleen.
Database Links

KEGG: rno:289747

STRING: 10116.ENSRNOP00000032548

UniGene: Rn.127158

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