Osm Antibody, FITC conjugated

Datasheet

Code	CSB-PA723970LC01RA
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Osm Polyclonal antibody

Uniprot No.

Q65Z15

Target Names

Osm

Alternative Names

Osm antibody; Oncostatin-M antibody; OSM antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Oncostatin-M protein (26-207AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Gene References into Functions

OSM is a key mediator for inducing differentiation of OC15-5 cells into hepatocytes PMID: 15743783
In the immortalized mouse and primary cultured proliferative rat hepatocytes, treatment with OSM markedly increased mRNA and protein of claudin-2 together with formation of developed networks of TJ strands. PMID: 17434483
OSM may not only play a role in the regulation of Sertoli cell proliferation and the initiation of spermatogenesis but may also play a role in the regulation of Leydig cell progenitor formation. PMID: 17996055
Results indicate that osteosarcoma cells stably producing OSM do not develop resistance to this cytokine and thus could be a valuable new tool to study the anti-cancer effect of OSM in vivo. PMID: 19168167

Subcellular Location

Secreted.

Protein Families

LIF/OSM family

Tissue Specificity

Widely expressed. Expressed at higher levels in liver, skin and spleen.

Database Links

KEGG: rno:289747

STRING: 10116.ENSRNOP00000032548

UniGene: Rn.127158

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Related pathways

Jak-STAT signaling pathway PI3K-Akt signaling pathway Target Therapy

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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