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Code | CSB-PA00254C0Rb |
Size | US$299 |
Have Questions? | Leave a Message or Start an on-line Chat |
Full Product Name | Rabbit anti-Homo sapiens (Human) P4HB Polyclonal antibody |
Uniprot No. | P07237 |
Target Names | P4HB |
Alternative Names | Cellular thyroid hormone binding protein antibody; Cellular thyroid hormone-binding protein antibody; Collagen prolyl 4 hydroxylase beta antibody; Disulphide Isomerase antibody; DSI antibody; EC 5.3.4.1 antibody; Endoplasmic reticulum resident protein 59 antibody; ER protein 59 antibody; ERBA2L antibody; ERp59 antibody; GIT antibody; Gltathione insulin transhydrogenase antibody; Glutathione insulin transhydrogenase antibody; P4HB antibody; P4Hbeta antibody; p55 antibody; PDI antibody; PDIA1 antibody; PDIA1_HUMAN antibody; PDIR antibody; PHDB antibody; PO4DB antibody; PO4HB antibody; Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1) antibody; Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit antibody; PROHB antibody; Prolyl 4 hydroxylase beta polypeptide antibody; Prolyl 4 hydroxylase beta subunit antibody; Prolyl 4 hydroxylase subunit beta antibody; Prolyl 4-hydroxylase subunit beta antibody; Protein disulfide isomerase associated 1 antibody; Protein disulfide isomerase, family A, member 1 antibody; Protein disulfide isomerase/oxidoreductase antibody; Protein disulfide-isomerase antibody; Protocollagen hydroxylase antibody; Thbp antibody; Thyroid hormone binding protein p55 antibody; Thyroid hormone binding protein p55 cellular antibody; V erb a avian erythroblastic leukemia viral oncogene homolog 2 like antibody |
Raised in | Rabbit |
Species Reactivity | Human |
Immunogen | Recombinant Human Protein disulfide-isomerase protein (29-508AA) |
Immunogen Species | Homo sapiens (Human) |
Conjugate | FITC |
Clonality | Polyclonal |
Isotype | IgG |
Purification Method | >95%, Protein G purified |
Concentration | It differs from different batches. Please contact us to confirm it. |
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Form | Liquid |
Troubleshooting and FAQs | Antibody FAQs |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function |
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
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Gene References into Functions |
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Involvement in disease | Cole-Carpenter syndrome 1 (CLCRP1) |
Subcellular Location | Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. |
Protein Families | Protein disulfide isomerase family |
Database Links |
HGNC: 8548 OMIM: 112240 KEGG: hsa:5034 STRING: 9606.ENSP00000327801 UniGene: Hs.464336 |