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| Code | CSB-PA020236 |
| Size | US$167 |
| Uniprot No. | O60260 |
| Protocols | Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol ELISA Protocol |
| Immunogen | Synthesized peptide derived from the N-terminal region of Human PARK2. |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | WB,IHC,IF,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000 |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Alias | PARK2; PRKN; E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2 |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | PRKN |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 |
| Involvement in disease | Parkinson disease (PARK); Parkinson disease 2 (PARK2) |
| Subcellular Location | Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion |
| Protein Families | RBR family, Parkin subfamily |
| Tissue Specificity | Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons fro |
| Database Links |
HGNC: 8607 OMIM: 168600 KEGG: hsa:5071 STRING: 9606.ENSP00000355865 UniGene: Hs.132954 |
| Pathway |
Protein processing in endoplasmic reticulum
Ubiquitin mediated proteolysis |
PRKN Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA017451KA01HU | PARK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA076233 | PARK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003708 | PARK2 Antibody | Human | WB,IHC,ELISA |
| CSB-PA020235 | Phospho-PARK2 (S131) Antibody | Human | WB,IHC,ELISA |
PRKN Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA017451LA01HU | PRKN Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA017451LB01HU | PRKN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017451LC01HU | PRKN Antibody, FITC conjugated | Human | ELISA |
| CSB-PA017451LD01HU | PRKN Antibody, Biotin conjugated | Human | ELISA |
PRKN Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-BP017451HUb1 | Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | Baculovirus |
| CSB-YP017451HU CSB-MP017451HU |
Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | Yeast Mammalian cell |
| CSB-EP017451HU | Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | E.coli |
| CSB-BP017451HU | Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | Baculovirus |
2-hydroxyisobutyryl-HIST1H2BC (K12) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H2BC (K24) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
