PCK2 Antibody, Biotin conjugated

Code CSB-PA619092LD01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PCK2 Polyclonal antibody
Uniprot No. Q16822
Target Names PCK2
Alternative Names EC 4.1.1.32 antibody; GTP mitochondrial precursor antibody; HGNC:8725 antibody; mitochondrial antibody; Mitochondrial phosphoenolpyruvate carboxykinase 2 antibody; OTTHUMP00000164700 antibody; PCK2 antibody; PCKGM_HUMAN antibody; PE antibody; PEP carboxykinase antibody; PEPCK antibody; PEPCK deficiency mitochondrial antibody; PEPCK M antibody; PEPCK-M antibody; PEPCK2 antibody; Phosphoenolpyruvate carboxykinase [GTP] antibody; Phosphoenolpyruvate carboxykinase 2 (mitochondrial) antibody; Phosphoenolpyruvate carboxykinase 2 mitochondrial antibody; Phosphoenolpyruvate carboxylase antibody; Phosphopyruvate carboxylase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Phosphoenolpyruvate carboxykinase [GTP], mitochondrial protein (101-400AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Gene References into Functions
  1. Our study indicates that the T allele of the rs4982856 single-nucleotide polymorphisms in the PCK2 gene may be a risk factor for glucose intolerance after kidney transplantation PMID: 29731064
  2. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma PMID: 28166201
  3. ApoA-IV colocalizes with NR4A1, which suppresses G6Pase and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose. PMID: 26556724
  4. Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine metabolism, increases anabolic metabolism and promotes mTORC1 activity. PMID: 26481663
  5. Mitochondrial PCK2 regulates metabolic adaptation and enables glucose-independent tumor growth in various neoplasms. PMID: 26474064
  6. When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B cells. PMID: 26036577
  7. PEPCK activity was elevated threefold in lung cancer samples over normal lungs and its activation mediates an adaptive response to glucose depletion in lung cancer. PMID: 24632615
  8. Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines. PMID: 24973213
  9. Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells. PMID: 24602180
  10. expression of HCV nonstructural component NS5A in Huh7 or primary hepatocytes stimulated PEPCK gene expression and glucose output in HepG2 cells. PMID: 22955269
  11. results reveal a novel link between glucose metabolism and the DNA damage signaling pathway and suggest a possible role for PEPCK and G6P in the DNA damage response PMID: 21733854
  12. Endoplasmic reticulum stress triggers suppression of AMPK while increasing C/EBPbeta and pCREB expression which activates PEPCK gene transcription. PMID: 20797423
  13. Results suggest that pepck2 gene expression is regulated by its 5' flanking region up to 822 bp, and 317 bp upstream of transcriptional start point. PMID: 15315819
  14. Wild-type AREBP, but not Ser(470) to Ala(470) substituted non-phosphorylating mutant, represses gene expression of the phosphoenolpyruvate carboxykinase (PEPCK), a key enzyme of gluconeogenesis. PMID: 17097062
  15. skeletal muscle PEPCK has a role in determining physical activity levels PMID: 19521512
  16. Increased transcriptional expression of PEPCK1 and G6Pc does not account for increased gluconeogenesis and fasting hyperglycemia in patients with type 2 diabetes mellitus. PMID: 19587243

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Involvement in disease Mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD)
Subcellular Location Mitochondrion.
Protein Families Phosphoenolpyruvate carboxykinase [GTP] family
Database Links

HGNC: 8725

OMIM: 261650

KEGG: hsa:5106

STRING: 9606.ENSP00000216780

UniGene: Hs.75812

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