PECAM1 Antibody

Datasheet
Code CSB-PA085447
Size US$299
Uniprot No. P16284
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA085447(PECAM1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA085447(PECAM1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: Jurkat cells, Primary antibody: CSB-PA085447(PECAM1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human PECAM1
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB,IHC;ELISA:1:1000-1:5000,WB:1:500-1:2000,IHC:1:25-1:100
Relevance The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias Platelet/endothelial cell adhesion molecule 1
Immunogen Species Homo sapiens (Human)
Target Names PECAM1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions
Subcellular Location Cell membrane, Single-pass type I membrane protein, Note=Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation, SUBCELLULAR LOCATION: Isoform Long: Cell membrane, Single-pass type I membrane protein, Membrane raft, Cell junction, Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells, SUBCELLULAR LOCATION: Isoform Delta15: Cell junction
Tissue Specificity Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580
Database Links

HGNC: 8823

OMIM: 173445

KEGG: hsa:5175

UniGene: Hs.376675

Pathway Leukocyte transendothelial migration

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