PECAM1 Antibody

Code CSB-PA116222
Size US$167
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  • Western Blot analysis of Hela cells using primary antibody diluted at 1:1000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
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Product Details

Uniprot No. P16284
Target Names PECAM1
Alternative Names Adhesion molecule antibody; CD31 antibody; CD31 antigen antibody; CD31 EndoCAM antibody; EndoCAM antibody; FLJ34100 antibody; FLJ58394 antibody; GPIIA antibody; GPIIA' antibody; PECA1 antibody; PECA1_HUMAN antibody; Pecam 1 antibody; PECAM 1 CD31 EndoCAM antibody; PECAM antibody; PECAM-1 antibody; Pecam1 antibody; Platelet and endothelial cell adhesion molecule 1 antibody; Platelet endothelial cell adhesion molecule antibody; Platelet/endothelial cell adhesion molecule 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from Human CD31. at AA range: Internal
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB,ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-2000
ELISA 1:10000-20000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions
Gene References into Functions
  1. High CD31 expression is associated with Central Giant Cell Granuloma. PMID: 30139237
  2. TNF-alpha and IL-10 treatment can affect the expression of ICAM-1 and CD31 in human coronary artery endothelial cells. PMID: 29949812
  3. High CD31 expression is associated with early-stage, but not in late-stage, laryngeal squamous cell carcinoma. PMID: 29523110
  4. Adenocarcinomas showed significantly higher staining scores of both VEGF and alphaSMA than squamous cell carcinomas did. In 42 cases of high CD31 score, five-year survival rate (87%) of patients with lung cancer showing mature tumor vessels was significantly better than that (69%) of patients with immature tumor vessels PMID: 29970531
  5. Differences in trafficking of CD31(+) cytotoxic T lymphocytes during acute influenza infection could modulate tolerance and contribute to a dampened adaptive immune response in neonates PMID: 28355204
  6. Cell adhesion assays on wildtype and mutant PECAM-1 further characterized the structural determinants in cell junction and communication. PMID: 27958302
  7. In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process. PMID: 27704157
  8. upregulation of sVEGFR-1 with concomitant decline of PECAM-1 and sVEGFR-2 levels in preeclampsia compared to normotensive pregnancies, Irrespective of the HIV status PMID: 28609170
  9. Increased expression of PECAM-1, ICAM-3, and VCAM-1 in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares; this suggests that increases in the expression of these proteins may be early events that lead to flares in patients with IBD. PMID: 27552332
  10. PECAM-1 gene polymorphisms are associated with Kawasaki disease with and without coronary artery lesions in Chinese children. PMID: 28512385
  11. Sirt1 expression is associated with CD31 expression in endothelial progenitor cells from patients with chronic obstructive pulmonary disease. PMID: 27784320
  12. we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 and P-Selectin genes in the risk of recurrent IVF-ET failures. The coexistence of these SNPs was associated with increased IVF-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF-ET failure, especially for younger women PMID: 28388872
  13. Dimer conformation of soluble PECAM-1 PMID: 27270333
  14. RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR PMID: 28515075
  15. this study shows a significant role for CD31 during T cell development PMID: 28159903
  16. Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 and VE-cadherin, and a significant increase in that of alpha-SMA and collagen I. PMID: 28347704
  17. Patients who had optic neuritis that progressed to multiple sclerosis had a decrease in serum PECAM-1 levels. PMID: 27806869
  18. Platelet endothelial cell adhesion molecule (PECAM-1) is expressed in endothelial cells (ECs), platelets, and leukocytes, regulating the interaction between those cells. PMID: 27079772
  19. Data indicate no association of maternal or fetal ITGA2 C807T SNP, ITGB3 T1565C SNP, PECAM1 CTG - GTG and SELP A/C polymorphisms with fetal growth restriction (FGR). PMID: 28358707
  20. these data suggest that a sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface. PMID: 27793989
  21. Decreased FoxP3 expression in CD31(+) Tr cells. PMID: 27997991
  22. These results suggested that PECAM-1 could mediate platelet adhesion to endothelial cells under shear stress. Platelets binding to endothelial cells interfered with endothelial cell mechanotransduction through PECAM-1, affecting endothelial cell inflammatory responses towards pathological shear flow. PMID: 28013181
  23. Immunohistochemical expression of CD31 and vascular endothelial growth factor (VEGF) were assessed in parallel. PMID: 27270504
  24. CD31 is expressed in mycosis fungoides (MF) skin biopsies, which provides new evidence for the role of angiogenesis in the progression of MF PMID: 27630298
  25. The Leu125Val polymorphism of PECAM-1 and the level of soluble PECAM-1 are not associated with diabetic nephropathy in Caucasians with type 2 diabetes mellitus. PMID: 28116228
  26. We provide the first report that pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in pathological dermal angiogenesis disorders of psoriasis. PMID: 26748901
  27. The PECAM-1 functions as an adhesive stress-response protein to both maintain endothelial cell junctional integrity and speed restoration of the vascular permeability barrier following inflammatory or thrombotic challenge. PMID: 27055047
  28. These studies indicate a role for PECAM-1 in enhancing the inhibitory functions of TGF-beta in T cells PMID: 26956486
  29. PECAM1 plays an important role in the formation of tight junction complex. PMID: 26607202
  30. The most significant associations were detected for PECAM1*V/V + DDAH1*C (OR = 4.17 CI 1.56-11.15 Pperm = 0.005) PMID: 26662939
  31. soluble CD38 (sCD38) in seminal plasma increases the capacitation of sperm via specific interactions between sCD38 and the CD31 on the sperm. PMID: 26407101
  32. expression levels of CD31/ PECAM1 are deregulated in human glioblastoma multiforme tissue specimens; correlation among CD31/PECAM1 and HIF-1alpha and N-cadherin and ADAM-10, two other markers of aggressiveness in the same tumors PMID: 26376118
  33. Radiation-induced stress conditions induce a transient accumulation of granulocytes within the liver by down-regulation/absence of PECAM-1. PMID: 26177067
  34. Suggest that CD31 expression correlates with prognosis in gastrointestinal stromal tumors. PMID: 26078569
  35. PECAM-1 125C/G polymorphism is associated with deep vein thrombosis. PMID: 25846278
  36. Heterogeneity was found in the endothelial cells: their shape, the expression of adhesion molecules(ICAM-1, VCAM-1, and PECAM ), and the adhesion of lymphocytes and monocytes to them changed during the progression of the atherosclerotic process. PMID: 26841644
  37. PECAM1+ melanoma cells form vascular channels PMID: 25335460
  38. Low shear stress can induce inflammatory response via PECAM-1/PARP-1/HMGB1 pathway. PMID: 25793984
  39. Nck promoted oxidative stress-induced activation of NF-kappaB by coupling the tyrosine phosphorylation of PECAM-1 (platelet endothelial cell adhesion molecule-1) to the activation of p21-activated kinase PMID: 25714462
  40. PECAM-1 has a role in mediating the profibrotic and prometastasic environment caused by ethanol in endothelial cells PMID: 24734240
  41. Report correlation between mast cell tryptase and CD31 expression in odontogenic tumors. PMID: 26247531
  42. there are associations between various PECAM-1 polymorphisms in rheumatoid arthritis and systemic lupus erythematosus patients, and PECAM-1 polymorphisms in SLE are protective against atherosclerotic complications PMID: 25201689
  43. preeclampsia does not significantly affect vascular growth or the expression of endothelial junction proteins in human placentas PMID: 25362142
  44. C-CD31 have impaired angiogenic potential and the number of circulating CD31(+) cells were correlated with cardiovascular disease risk PMID: 25267411
  45. demonstrate a functional link between HO-1 gene expression and PECAM-1 in endothelial cells, which might play a critical role in the regulation of inflammation PMID: 24500083
  46. The positive correlation is established between content of polymorphic nuclear monocytes and level of expression of molecules of LFA-1, ICAM-1, LFA-3, and PECAM-1. PMID: 25884075
  47. High CD31 expression associated significantly with better survival and VEGFR3 had no association with survival. Both higher tumor grade and stage were associated with a decreased survival time PMID: 25667475
  48. Suggest that cell confluence and the type of flow are critical independent factors in the induction of TF and PECAM-1 phosphorylation in endothelial cells exposed to disturbed pulsatile flow and chemical stimuli. PMID: 24342062
  49. The finding that the adhesive properties of PECAM-1 are regulatable suggests novel approaches for controlling endothelial cell migration and barrier function in a variety of vascular permeability disorders. PMID: 24936065
  50. for the cytological diagnosis of angiosarcomas, ERG and CD31 are more sensitive vascular markers than CD34 PMID: 25352641
  51. PECAM is a sialic acid binding lectin and that this binding property supports endothelial cell survival. PMID: 25135639
  52. S. pneumoniae physically binds to PECAM-1. PMID: 24914219
  53. Activation of PECAM-1 inhibits the binding of thrombin to human platelets and their subsequent activation. PECAM-1 cross-linking reduces the levels of GPIbalpha at the cell surface. PMID: 24969778
  54. Results suggest that contrast-enhancing medulloblastomas in pediatric patients are able to attract new microvessels, as noted by increased microvessel density and robust CD31 expression. PMID: 24905841
  55. Esophageal cancer tissues showed positive expression of FGF-2, CD31, and SMA; in contrast, FGF-2 expression was not detected and only little staining for CD31 and SMA was noted in normal epithelium PMID: 24777337
  56. results of the current meta-analysis suggest that homozygous polymorphic genotype (GG) of the rs1131012 SNP may confer protection against myocardial infarction PMID: 23906939
  57. CD31 expression on human PBSCs may positively affect both neutrophil and platelet engraftment. PMID: 24025427
  58. the PECAM-1.Galphaq/11 mechanosensitive complex contains an endogenous heparan sulfate proteoglycan with HS chains that is critical for junctional complex assembly and regulating the flow response PMID: 24497640
  59. SAP is a new actor downstream of PECAM-1 and its binding regulates PECAM-1 mediated cell adhesion. PMID: 24388971
  60. 8 of 10 cases of blastic plasmacytoid dendritic cell neoplasm were CD31/PECAM-1 positive. PMID: 24225899
  61. CD31(+) cells exclusively showed higher colony-forming activity. PMID: 22188988
  62. PECAM-1 may play a role in regulation of apoptosis as well as adhesion of BCR/ABL-expressing cells to modulate their imatinib sensitivity and would be a possible candidate for therapeutic target in Ph+ leukemias. PMID: 23233201
  63. PECAM-1 has a regulatory role in venous thrombus resolution. PMID: 24081660
  64. Data indicate a fundamental role of PECAM-1 in the inhibitory effects of statins on platelet activation. PMID: 24030383
  65. Increased expression of VEGF and CD31 in postradiation rectal tissue: implications for radiation proctitis. PMID: 23737650
  66. High microvessel density of PECAM-1 in non-small-cell lung cancer patients was correlated with poor overall survival. PMID: 23494670
  67. Through phenotype analysis, non-HAV-specific antibody-secreting cells (ASCs) are found to be Ki-67lowCD138highCD31highCD38high compared with hepatitis A virus-specific ASCs. PMID: 23729443
  68. sequential phosphorylation of PECAM-1 in platelets activated via the immunoreceptor tyrosine-based activation motifs-coupled GPVI collagen receptor and initial phosphorylation of the PECAM-1 cytoplasmic domain enables its subsequent phosphorylation PMID: 23418871
  69. PECAM1+/CD38+ Vascular Cells can be Identified in Human Foreskin and in Vascular Sprouts of Basal Cell Carcinomas. PMID: 23308177
  70. The increased CD105/CD31 and VEGF/CD31 ratios in gingiva confirms an augmented proliferative fraction of the endothelium in gingiva with chronic periodontitis. PMID: 23264219
  71. Levels of PECAM-1 and P-selectin were significantly reduced in the autism spectrum disorder group compared to typically developing controls PMID: 22717029
  72. Suggest that the PECAM-1 125 Val/leu polymorphism might be a genetic factor that may be associated with asthma. PMID: 23264403
  73. The immunohistochemical expressions of PECAM-1 and E-selectin were significantly increased at intima in vulnerable plaques of acute coronary syndrome patients. PMID: 22336504
  74. explanation for the weak and often inconsistent CD31 immunohistochemical staining that is observed in Kaposi sarcoma PMID: 23106575
  75. The findings of a decrease of PECAM-1 expression and an increase of ICAM-1 expression in preeclamptic placenta suggest the existence of functional roles of these adhesion molecules in the pathophysiology of preeclampsia. PMID: 22396143
  76. reticular adherens junctions act coordinately with PECAM-1 to maintain endothelial barrier function in regions of low actomyosin-mediated tension. PMID: 22723439
  77. Linoleic acid enhanced PECAM-1 expression independently of tumor necrosis factor (TNF)-alpha and significantly increased TNF-alpha-induced monocyte adhesion to human aortic endothelial cells. PMID: 21840193
  78. Loss of CD31 is associated with metastasis in clear-cell renal cell carcinoma. PMID: 22213152
  79. In clear cell renal cell carcinoma, increased endoglin and CD31 expression are associated with a higher tumor stage and decreased progression-free survival. PMID: 22204709
  80. soluble PECAM-1 levels increased in polycystic ovary syndrome, contribute to endothelial dysfunction PMID: 22456311
  81. analysis of CD105, CD31, alpha-SMA, vimentin and desmin expression on a series of normal human heart tissues varying between five and 33 weeks PMID: 22395512
  82. We show that knockdown of ZDHHC21 leads to reduced levels of platelet endothelial cell adhesion molecule-1 at the cell surface. PMID: 22496122
  83. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) and CD99 are critical in lymphatic transmigration of human dendritic cells. PMID: 22189791
  84. Data show there are no differences in the distribution of immunohistochemical reactivity for CD31, CD34, D2-40, or FLI1 between AIDS-related and non-AIDS-related Kaposi sarcoma (KS) or between nodular- and patch/plaque-stage KS. PMID: 22372906
  85. findings suggest the possible existence of both PECAM-1-related monocyte migration at peri-junctional sites and PECAM-1-unrelated migration at sites remote from junctions. PMID: 22109690
  86. Report role of mechanotransducer CD31 in modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress. PMID: 21898411
  87. The positive feedback mechanism at endothelial junctions is partially associated with monocyte transmigration-induced local accumulation of endothelial PECAM-1, which promotes transmigration of monocytes at the same location. PMID: 21190742
  88. In all cases of pulmonary epithelioid haemangioendothelioma, the cytoplasm of tumour cells showed widespread expression of CD-31. PMID: 22246909
  89. Syk protein tyrosine kinase involves PECAM-1 signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages. PMID: 22000807
  90. Studies suggest that PECAM-1-PECAM-1 homophilic interactions are more important than its signaling function for maintaining the integrity of endothelial cell junctions. PMID: 21486942
  91. PECAM-1-mediated inhibition of GPVI-dependent platelet responses result from recruitment of SHP-2-p85 complexes to tyrosine-phosphorylated PECAM-1, which diminishes the association of PI3K with activatory signaling molecules Gab1 and LAT PMID: 20723025
  92. The expressions of CD31 and CD34 are not correlated with tumor grade and stage in chromophobe or papillary renal cell carcinoma. PMID: 20403242
  93. Numerical and functional impairments in CD31-positive T-cell subpopulation may contribute to diminished angiogenic potential and greater cardiovascular risk with advancing age. PMID: 20864561
  94. novel pathway for PECAM-1 regulation PMID: 20724702
  95. Angiogenesis-associated molecules like CD105 and CD31 might be useful tools as prognostic markers in intraductal papillary mucinous neoplasm of the pancreas. PMID: 20712008
  96. The findings suggest that permanent silencing of PECAM-1 expression is feasible and contributes to efficiently inhibiting the cytotoxic T-cell response to allogeneic target cells. PMID: 20492609
  97. The SNP at position +1688 in the exon 8 of PECAM-1 gene was associated with myocardial infarction and the allele A might be a risk factor for MI in the Chinese Han population. PMID: 18060625
  98. mRNA levels of CD31, CD144, CD146 and vWf in whole blood as detected by real time RT-PCR cannot be used as biomarkers for end-stage endothelial cells such as circulating endothelial cells. PMID: 20589320
  99. was a positive correlation between CD31 and VEGF expression when all adenoma histotypes were considered, or when prolactinomas and nonfunctioning adenomas were evaluated separately PMID: 20473646
  100. PECAM-1 functions by modulating ITAM-mediated signaling pathways that amplify cellular activation PMID: 20403098

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Subcellular Location Cell membrane, Single-pass type I membrane protein, Note=Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation, SUBCELLULAR LOCATION: Isoform Long: Cell membrane, Single-pass type I membrane protein, Membrane raft, Cell junction, Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells, SUBCELLULAR LOCATION: Isoform Delta15: Cell junction
Tissue Specificity Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580
Database Links

HGNC: 8823

OMIM: 173445

KEGG: hsa:5175

UniGene: Hs.376675

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