Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PLA2G4C Polyclonal antibody

Uniprot No.

Q9UP65

Target Names

PLA2G4C

Alternative Names

cPLA2 gamma antibody; Cytosolic phospholipase A2 gamma antibody; EC 3.1.1.4 antibody; PA24C_HUMAN antibody; Phospholipase A2 group IVC antibody; PLA2G4C antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human PLA2G4C.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles. Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids. Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency. In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles.; (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur. Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly.; (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission.

Gene References into Functions

Five single-nucleotide polymorphisms (SNPs) (rs9226, rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A were selected and genotyped. Our results showed a significant association between ASD and the rs251684 variant of PLA2G4C. The rs251684 polymorphism of PLA2G4C may be associated with Autism Spectrum Disorder risk. PMID: 27611910
The A allele in PLA2G4C single nucleotide polymorphism (rs1549637) is associated with a worse prognosis in patients with colorectal cancer, especially in stage II. PMID: 26364726
site-specific cytosine methylation of the CpT of PLA2G4C may play a role in the pathogenesis of schizophrenia. PMID: 22878031
These findings suggest that IVC-PLA(2) is involved in regulations of macrophage differentiation and macrophage polarization. PMID: 22108055
these results suggest that cPLA(2)gamma plays an important role in cancer cell chemotaxis. PMID: 21600875
Findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor. PMID: 21184677
cPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia PMID: 20452986
locus showed a weak association with schizophrenia in a Chinese population PMID: 20016400
Novel PLA2G4C polymorphism as a molecular diagnostic A minisatellite polymorphism in the untranslated region of exon 1, with allelic variants that have one, two or three 27-bp repeats PMID: 11958371
enzymatic properties PMID: 12039969
TNF-alpha & IFN-gamma induce gene expression of a novel cytosolic PLA(2) IVC in human airway epithelial cells. The possibility that it is involved in cytokine-mediated inflammation in the respiratory tract is inferred. PMID: 12396716
Down-regulation of Phospholipase A2 is associated with colon tumorigenesis PMID: 15788676
identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine PMID: 15908428
results indicate that complete C-terminal processing is important for the functional expression of cPLA2, although not for its membrane localization PMID: 15944408
Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells PMID: 16882668
iPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts PMID: 17213206
Single nucleotide polymorphism is asociated with schizzophrenia in a Chinese population. PMID: 17417066
endometrial cell PGE2 biosynthesis was associated with PLA2G4C expression and activity PMID: 17459165
The subcellular localization and enzymatic properties of cPLA2gamma with C-terminal FLAG-tag, was examined. PMID: 19501189

Hide All

Subcellular Location

Cell membrane; Lipid-anchor. Endoplasmic reticulum membrane; Lipid-anchor. Mitochondrion membrane; Lipid-anchor. Lipid droplet.

Tissue Specificity

Highly expressed in heart and skeletal muscle.

Database Links

HGNC: 9037

OMIM: 603602

KEGG: hsa:8605

STRING: 9606.ENSP00000400036

UniGene: Hs.631562

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Code	CSB-PA930276
Size	US$297
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Image	Western blot analysis of extracts from Jurkat cells, using PLA2G4C antibody.
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PLA2G4C Antibody

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