PLAT Antibody

Datasheet
Code CSB-PA030068
Size US$167
Uniprot No. P00750
Image
  • Western Blot analysis of A549 cells using tPA Polyclonal Antibody
Immunogen Synthesized peptide derived from the N-terminal region of Human tPA.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Target Names PLAT
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Involvement in disease Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
Subcellular Location Secreted, extracellular space
Protein Families Peptidase S1 family
Tissue Specificity Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Database Links

HGNC: 9051

OMIM: 173370

KEGG: hsa:5327

STRING: 9606.ENSP00000220809

UniGene: Hs.491582

Pathway Complement and coagulation cascades
Apelin signaling pathway

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