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| Code | CSB-PA111403 |
| Size | US$299 |
| Uniprot No. | P00750 |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Immunogen | Synthetic peptide of Human PLAT |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA,WB,IHC;ELISA:1:1000-1:5000,WB:1:200-1:1000,IHC:1:50-1:200 |
| Relevance | This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method | Antigen affinity purification |
| Isotype | IgG |
| Alias | plasminogen activator, tissue |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | PLAT |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. |
| Involvement in disease | Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. |
| Subcellular Location | Secreted, extracellular space |
| Protein Families | Peptidase S1 family |
| Tissue Specificity | Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk. |
| Database Links |
HGNC: 9051 OMIM: 173370 KEGG: hsa:5327 STRING: 9606.ENSP00000220809 UniGene: Hs.491582 |
| Pathway |
Complement and coagulation cascades
Apelin signaling pathway |
PLAT Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA018120GA01HU | PLAT Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA11819B0Rb | PLAT Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11819C0Rb | PLAT Antibody, FITC conjugated | Human | ELISA |
| CSB-PA11819D0Rb | PLAT Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA030068 | PLAT Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA255864 | PLAT Antibody | Human | ELISA,WB,IHC |
PLAT Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA11819A0Rb | PLAT Antibody | Human, Mouse | ELISA, WB, IHC |
PLAT Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP018120HU CSB-BP018120HU CSB-MP018120HU |
Recombinant Human Tissue-type plasminogen activator(PLAT),partial | Yeast Baculovirus Mammalian cell |
| CSB-EP018120HU | Recombinant Human Tissue-type plasminogen activator(PLAT),partial | E.coli |
| CSB-YP018120HU(A5) CSB-BP018120HU(A5) CSB-MP018120HU(A5) |
Recombinant human Tissue-type plasminogen activator | Yeast Baculovirus Mammalian cell |
| CSB-EP018120HU(A5) | Recombinant Human Tissue-type plasminogen activator(PLAT),partial | E.coli |
PLAT ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E07916h | Human Tissue-type Plasiminogen Actilyse,t-PA ELISA Kit | serum, palsma, tissue homogenates. | 0.039 ng/ml |
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K5) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
