PPP1R15A Antibody

Datasheet
Code CSB-PA018528GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. O75807
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human PPP1R15A,GADD34
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,WB
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias protein phosphatase 1, regulatory (inhibitor) subunit 15A;PPP1R15A;GADD34 ;
Immunogen Species Homo sapiens (Human)
Target Names PPP1R15A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
HGNC 14375
RGD 621526
MGI 1927072
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Function Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Subcellular Location Endoplasmic reticulum membrane, Peripheral membrane protein, Cytoplasmic side, Mitochondrion outer membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families PPP1R15 family
Database Links

HGNC: 14375

OMIM: 611048

KEGG: hsa:23645

STRING: 9606.ENSP00000200453

UniGene: Hs.631593

Pathway Protein processing in endoplasmic reticulum
ER Stress pathway

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