PPP1R15A Antibody

Datasheet
Code CSB-PA787946
Size US$167
Uniprot No. O75807
Image
  • Western blot analysis of MOUSE-BRAIN lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Immunogen Synthetic peptide from Human protein at AA range: 430-490
Raised in Rabbit
Species Reactivity Human
Tested Applications WB,ELISA;WB:1:500-2000,ELISA:1:10000-20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alias Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)
Immunogen Species Homo sapiens (Human)
Target Names PPP1R15A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Subcellular Location Endoplasmic reticulum membrane, Peripheral membrane protein, Cytoplasmic side, Mitochondrion outer membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families PPP1R15 family
Database Links

HGNC: 14375

OMIM: 611048

KEGG: hsa:23645

STRING: 9606.ENSP00000200453

UniGene: Hs.631593

Pathway Protein processing in endoplasmic reticulum
ER Stress pathway

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