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PPP2R5D Antibody

Datasheet
Code CSB-PA143410
Size US$297
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Image
  • Western blot analysis of extracts from HuvEc cells and Jurkat cells, using PPP2R5D antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PPP2R5D Polyclonal antibody
Uniprot No.
Q14738
Target Names
PPP2R5D
Alternative Names
2A5D_HUMAN antibody; B'delta antibody; B56D antibody; Delta isoform of regulatory subunit B56; protein phosphatase 2A antibody; MGC2134 antibody; MGC8949 antibody; OTTHUMP00000039821 antibody; PP2A B subunit B' delta isoform antibody; PP2A B subunit B56 delta isoform antibody; PP2A B subunit isoform B''-delta antibody; PP2A B subunit isoform B56-delta antibody; PP2A B subunit isoform PR61-delta antibody; PP2A B subunit isoform R5-delta antibody; PP2A B subunit PR61 delta isoform antibody; PP2A B subunit R5 delta isoform antibody; PPP2R5D antibody; Protein phosphatase 2 regulatory subunit B (B56) delta isoform antibody; Protein phosphatase 2 regulatory subunit B delta isoform antibody; Protein phosphatase 2 regulatory subunit B' delta antibody; Serine threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; TEG-271 antibody; Tex271 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human PPP2R5D.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PPP2R5D Antibodies

PPP2R5D Proteins

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Target Background

Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Gene References into Functions
  1. Mutations in PPP2R5D are genetic cause of intellectual disability. PMID: 26576547
  2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. PMID: 25772595
  3. Mutant B56delta was A and C binding-deficient, while mutant Aalpha subunits bound B56delta well but were unable to bind C PMID: 26168268
  4. PP2A-B56delta is the single most significant contributor, of the PP2A holoenzyme subunits, to BubR1 and Bub1 kinetochore localization. PMID: 25246613
  5. Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates. PMID: 20423611
  6. Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 and -2, but not other basic helix-loop-helix proteins. PMID: 14636580
  7. Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells. PMID: 15809743
  8. PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis PMID: 18056802

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Involvement in disease
Mental retardation, autosomal dominant 35 (MRD35)
Subcellular Location
Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
Protein Families
Phosphatase 2A regulatory subunit B56 family
Tissue Specificity
Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
Database Links

HGNC: 9312

OMIM: 601646

KEGG: hsa:5528

STRING: 9606.ENSP00000417963

UniGene: Hs.533308

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Related pathways
PI3K-Akt signaling pathway AMPK signaling Sphingolipid signaling pathway
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