PPP2R5D Antibody

Code CSB-PA143410
Size US$297 How to order?
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  • Western blot analysis of extracts from HuvEc cells and Jurkat cells, using PPP2R5D antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PPP2R5D Polyclonal antibody
Uniprot No. Q14738
Target Names PPP2R5D
Alternative Names 2A5D_HUMAN antibody; B'delta antibody; B56D antibody; Delta isoform of regulatory subunit B56; protein phosphatase 2A antibody; MGC2134 antibody; MGC8949 antibody; OTTHUMP00000039821 antibody; PP2A B subunit B' delta isoform antibody; PP2A B subunit B56 delta isoform antibody; PP2A B subunit isoform B''-delta antibody; PP2A B subunit isoform B56-delta antibody; PP2A B subunit isoform PR61-delta antibody; PP2A B subunit isoform R5-delta antibody; PP2A B subunit PR61 delta isoform antibody; PP2A B subunit R5 delta isoform antibody; PPP2R5D antibody; Protein phosphatase 2 regulatory subunit B (B56) delta isoform antibody; Protein phosphatase 2 regulatory subunit B delta isoform antibody; Protein phosphatase 2 regulatory subunit B' delta antibody; Serine threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; TEG-271 antibody; Tex271 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from internal of Human PPP2R5D.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Gene References into Functions
  1. Mutations in PPP2R5D are genetic cause of intellectual disability. PMID: 26576547
  2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. PMID: 25772595
  3. Mutant B56delta was A and C binding-deficient, while mutant Aalpha subunits bound B56delta well but were unable to bind C PMID: 26168268
  4. PP2A-B56delta is the single most significant contributor, of the PP2A holoenzyme subunits, to BubR1 and Bub1 kinetochore localization. PMID: 25246613
  5. Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates. PMID: 20423611
  6. Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 and -2, but not other basic helix-loop-helix proteins. PMID: 14636580
  7. Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells. PMID: 15809743
  8. PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis PMID: 18056802

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Involvement in disease Mental retardation, autosomal dominant 35 (MRD35)
Subcellular Location Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
Protein Families Phosphatase 2A regulatory subunit B56 family
Tissue Specificity Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
Database Links

HGNC: 9312

OMIM: 601646

KEGG: hsa:5528

STRING: 9606.ENSP00000417963

UniGene: Hs.533308

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