PPP2R5D Antibody

Datasheet

Code	CSB-PA245104
Size	US$100
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Image	Western Blot analysis of 293T cells using PP2A-B56-δ Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q14738

Target Names

PPP2R5D

Alternative Names

2A5D_HUMAN antibody; B'delta antibody; B56D antibody; Delta isoform of regulatory subunit B56; protein phosphatase 2A antibody; MGC2134 antibody; MGC8949 antibody; OTTHUMP00000039821 antibody; PP2A B subunit B' delta isoform antibody; PP2A B subunit B56 delta isoform antibody; PP2A B subunit isoform B''-delta antibody; PP2A B subunit isoform B56-delta antibody; PP2A B subunit isoform PR61-delta antibody; PP2A B subunit isoform R5-delta antibody; PP2A B subunit PR61 delta isoform antibody; PP2A B subunit R5 delta isoform antibody; PPP2R5D antibody; Protein phosphatase 2 regulatory subunit B (B56) delta isoform antibody; Protein phosphatase 2 regulatory subunit B delta isoform antibody; Protein phosphatase 2 regulatory subunit B' delta antibody; Serine threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; TEG-271 antibody; Tex271 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human PP2A-B56-δ.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene References into Functions

Mutations in PPP2R5D are genetic cause of intellectual disability. PMID: 26576547
MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. PMID: 25772595
Mutant B56delta was A and C binding-deficient, while mutant Aalpha subunits bound B56delta well but were unable to bind C PMID: 26168268
PP2A-B56delta is the single most significant contributor, of the PP2A holoenzyme subunits, to BubR1 and Bub1 kinetochore localization. PMID: 25246613
Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates. PMID: 20423611
Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 and -2, but not other basic helix-loop-helix proteins. PMID: 14636580
Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells. PMID: 15809743
PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis PMID: 18056802

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Involvement in disease

Mental retardation, autosomal dominant 35 (MRD35)

Subcellular Location

Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.

Protein Families

Phosphatase 2A regulatory subunit B56 family

Tissue Specificity

Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.

Database Links

HGNC: 9312

OMIM: 601646

KEGG: hsa:5528

STRING: 9606.ENSP00000417963

UniGene: Hs.533308

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

PI3K-Akt signaling pathway AMPK signaling Sphingolipid signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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