PPP3CC Antibody

Datasheet

Code	CSB-PA018574ESR2HU
Size	US$166
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Image	Western blot All lanes: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform antibody at 8μg/ml Lane 1: Rat brain tissue Lane 2: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 59, 58, 60 kDa Observed band size: 59 kDa Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA018574ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA018574ESR2HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PPP3CC Polyclonal antibody

Uniprot No.

P48454

Target Names

PPP3CC

Alternative Names

calcineurin A gamma antibody; CALCINEURIN A3 antibody; Calcineurin antibody; Calcineurin testis specific catalytic subunit antibody; Calmodulin dependent calcineurin A subunit gamma isoform antibody; Calmodulin-dependent calcineurin A subunit gamma isoform antibody; CALNA3 antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA3 antibody; pp2b gamma Antibody antibody; PP2BC_HUMAN antibody; PP2Bgamma Antibody antibody; PPP3CC antibody; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform (calcineurin A gamma) antibody; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform antibody; testis-specific catalytic subunit antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform protein (373-512AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.

Gene References into Functions

PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk. PMID: 29275364
These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas. PMID: 29294030
The rs2443504 AA genotype was associated with the Glasgow coma score at 3, 6, and 12 months following severe brain injury. PMID: 27225880
Knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in hippocampal neurons. PMID: 26627835
The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation. PMID: 24709691
protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2+ signaling pathway PMID: 23747857
study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender PMID: 23497497
This study demoistrated that PPP3CC are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis PMID: 12851458
Decreased hippocampal expression of the susceptibility gene PPP3CC in schizophrenia. PMID: 15820226
PPP3CC may not play a major role in Japanese schizophrenia PMID: 15843870
The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia. PMID: 17339875
The Polymorphism, Single Nucleotide of ppp3cc is assosciated with schizophrenia. PMID: 17895921
No significant differences in calcineurin A gamma expression was observed between patients with schizophrenia and normal controls PMID: 18343007
Data suggest that PPP3CC does not elevate the risk of methamphetamine-use disorder in the Japanese population. PMID: 18991849

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Protein Families

PPP phosphatase family, PP-2B subfamily

Tissue Specificity

Testis.

Database Links

HGNC: 9316

OMIM: 114107

KEGG: hsa:5533

STRING: 9606.ENSP00000240139

UniGene: Hs.731683

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway MAPK signaling pathway VEGF signaling pathway Wnt signaling pathway Cellular senescence B cell receptor signaling pathway Natural killer cell mediated cytotoxicity Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation cGMP-PKG signaling pathway Glucagon signaling pathway Glutamatergic synapse

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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