SOST Antibody

Datasheet
Code CSB-PA858415ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9BQB4
Image
  • Western blot
    All lanes: SOST antibody at 4μg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 24 kDa
    Observed band size: 24 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA858415ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA858415ESR2HU at dilution of 1:100

Immunogen Recombinant Human Sclerostin protein (24-213AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200
Relevance Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Sclerostin, SOST
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Stem Cells
Target Names SOST
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Involvement in disease Sclerosteosis 1 (SOST1); Van Buchem disease (VBCH); Craniodiaphyseal dysplasia autosomal dominant (CDD)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Sclerostin family
Tissue Specificity Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).
Database Links

HGNC: 13771

OMIM: 122860

KEGG: hsa:50964

STRING: 9606.ENSP00000301691

UniGene: Hs.349204

Pathway Wnt signaling pathway

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