TNFRSF4 Antibody

Datasheet
Code CSB-PA023981GA01HU
Product Type Purified Rabbit Anti Human PolyClonal Antibody
Size US$685
Uniprot No. P43489
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human TNFRSF4
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,WB
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias tumor necrosis factor receptor superfamily, member 4;TNFRSF4;ACT35;CD134;OX40;TXGP1L ;
Immunogen Species Homo sapiens (Human)
Target Names TNFRSF4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
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Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Involvement in disease Immunodeficiency 16 (IMD16)
Subcellular Location Membrane, Single-pass type I membrane protein
Database Links

HGNC: 11918

OMIM: 600315

KEGG: hsa:7293

STRING: 9606.ENSP00000368538

UniGene: Hs.129780

Pathway Target Therapy

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