TNFRSF4 Research Reagents

TNFRSF4, usually called CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors for TNFSF4/OX40L/GP34 and is a costimulatory molecule implicated in long-term T-cell immunity. Unlike CD28, this receptor is not constitutively expressed on resting naïve T cells. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels.

The following TNFRSF4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.